Abstract：
BACKGROUND: Haemophagocytic lymphohistiocytosis (HLH) is a rare complication of dengue fever with potentially life-threatening consequences and high mortality. Therefore, this study aims to investigate the prevalence, management and outcome of HLH in dengue fever.
METHODS: The major electronic databases, including PubMed, ScienceDirect and Ovid SP, were searched from inception until 31 January 2024 to identify relevant studies. Pooled prevalence and mortality were calculated using the random-effects generic inverse variance model with a 95% CI. All the statistical analysis was conducted using R programming.
RESULTS: A total of nine studies with 157 patients with HLH, 576 patients with severe dengue and 5081 patients with dengue fever were included in this meta-analysis. The prevalence of HLH in severe dengue (22.1%, 95% CI 8.07 to 48.0%) was significantly higher than the prevalence in dengue fever (3.12%, 95% CI 0.37 to 21.9%). The prevalence of HLH in severe dengue was higher in the paediatric population (22.8%, 95% CI 3.9 to 68.4%) compared with the adult population (19.0%, 95% CI 3.0 to 63.9%). The overall mortality rate was 20.2% (95% CI 9.7 to 37.2%).
CONCLUSIONS: The prevalence of dengue-associated HLH was low in patients with dengue fever but is significantly higher in patients with severe dengue and a high mortality rate.
METHODS: The major electronic databases, including PubMed, ScienceDirect and Ovid SP, were searched from inception until 31 January 2024 to identify relevant studies. Pooled prevalence and mortality were calculated using the random-effects generic inverse variance model with a 95% CI. All the statistical analysis was conducted using R programming.
RESULTS: A total of nine studies with 157 patients with HLH, 576 patients with severe dengue and 5081 patients with dengue fever were included in this meta-analysis. The prevalence of HLH in severe dengue (22.1%, 95% CI 8.07 to 48.0%) was significantly higher than the prevalence in dengue fever (3.12%, 95% CI 0.37 to 21.9%). The prevalence of HLH in severe dengue was higher in the paediatric population (22.8%, 95% CI 3.9 to 68.4%) compared with the adult population (19.0%, 95% CI 3.0 to 63.9%). The overall mortality rate was 20.2% (95% CI 9.7 to 37.2%).
CONCLUSIONS: The prevalence of dengue-associated HLH was low in patients with dengue fever but is significantly higher in patients with severe dengue and a high mortality rate.
摘要：
背景：噬血细胞性淋巴组织细胞增生症（HLH）是登革热的一种罕见并发症，具有潜在的危及生命的后果和高死亡率。因此,这项研究旨在调查患病率，登革热HLH的治疗和结局。
方法：主要的电子数据库，包括PubMed,科学直接和奥维德SP，从开始到2024年1月31日进行搜索，以确定相关研究。使用具有95%CI的随机效应通用逆方差模型计算合并的患病率和死亡率。所有统计分析均使用R编程进行。
结果：共9项研究，共157例HLH患者，576例严重登革热患者和5081例登革热患者纳入本荟萃分析。严重登革热中HLH的患病率（22.1％，95%CI8.07~48.0%)显著高于登革热患病率(3.12%,95%CI0.37至21.9%）。重症登革热中HLH的患病率在儿科人群中较高(22.8%,95%CI3.9至68.4%）与成年人群（19.0%，95%CI3.0至63.9%）。总死亡率为20.2%（95%CI9.7至37.2%）。
结论：登革热患者的登革热相关HLH患病率较低，但严重登革热患者的HLH患病率明显较高，死亡率较高。
方法：主要的电子数据库，包括PubMed,科学直接和奥维德SP，从开始到2024年1月31日进行搜索，以确定相关研究。使用具有95%CI的随机效应通用逆方差模型计算合并的患病率和死亡率。所有统计分析均使用R编程进行。
结果：共9项研究，共157例HLH患者，576例严重登革热患者和5081例登革热患者纳入本荟萃分析。严重登革热中HLH的患病率（22.1％，95%CI8.07~48.0%)显著高于登革热患病率(3.12%,95%CI0.37至21.9%）。重症登革热中HLH的患病率在儿科人群中较高(22.8%,95%CI3.9至68.4%）与成年人群（19.0%，95%CI3.0至63.9%）。总死亡率为20.2%（95%CI9.7至37.2%）。
结论：登革热患者的登革热相关HLH患病率较低，但严重登革热患者的HLH患病率明显较高，死亡率较高。
