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Abstract：
UNASSIGNED: Inflammation is a central driver of atherogenesis and eventual plaque rupture. This study aimed to evaluate the association between residual inflammatory risk (RIR) and vulnerable plaques in the carotid artery in patients with ischemic stroke.
UNASSIGNED: Patients with acute ischemic stroke were enrolled from January 2021 to July 2022. They were divided into four groups: RIR only (LDL-C <2.6 mmol/L and hsCRP ≥2 mg/L), residual cholesterol risk (RCR) only (LDL-C ≥2.6 mmol/L and hsCRP <2 mg/L), both risk or residual cholesterol and inflammatory risk (RCIR) (LDL-C ≥2.6 mmol/L and hsCRP ≥2 mg/L), and neither risk (LDL-C <2.6 mmol/L and hsCRP <2 mg/L). Vulnerable plaques were determined if it had a low attenuated plaque CT value of <35 Hounsfield Units (HU) and a remodeling index of >1.1, which indicated a positive remodeling.
UNASSIGNED: Out of the 468 enrolled patients, 157 (33.5%) were detected to have vulnerable plaques. The proportion of patients with neither risk, RIR, RCR, and RCIR were 32.9%, 28.6%, 18.8%, and 19.7%, respectively. Patients with vulnerable plaques exhibited a higher prevalence of hyperlipidemia (P = 0.026), higher proportion of RIR (P = 0.015), a higher ratio of stroke subtypes of large artery atherosclerosis (P = 0.012), and high leukocyte counts (P < 0.001). The logistic regression analysis detected that RIR was associated with vulnerable plaques after adjusted for major confounding factors (OR 1.98, 95% CI 1.13-3.45, P = 0.016), especially in the large artery atherosclerosis subtype (OR 2.71, 95% CI 1.08-6.77, P = 0.034).
UNASSIGNED: In patients with ischemic stroke, RIR is associated with the vulnerability of carotid plaques, especially for those with the large artery atherosclerosis subtype. Therefore, further studies investigating the interventions to modulate inflammation in these patients may be warranted.
UNASSIGNED: Patients with acute ischemic stroke were enrolled from January 2021 to July 2022. They were divided into four groups: RIR only (LDL-C <2.6 mmol/L and hsCRP ≥2 mg/L), residual cholesterol risk (RCR) only (LDL-C ≥2.6 mmol/L and hsCRP <2 mg/L), both risk or residual cholesterol and inflammatory risk (RCIR) (LDL-C ≥2.6 mmol/L and hsCRP ≥2 mg/L), and neither risk (LDL-C <2.6 mmol/L and hsCRP <2 mg/L). Vulnerable plaques were determined if it had a low attenuated plaque CT value of <35 Hounsfield Units (HU) and a remodeling index of >1.1, which indicated a positive remodeling.
UNASSIGNED: Out of the 468 enrolled patients, 157 (33.5%) were detected to have vulnerable plaques. The proportion of patients with neither risk, RIR, RCR, and RCIR were 32.9%, 28.6%, 18.8%, and 19.7%, respectively. Patients with vulnerable plaques exhibited a higher prevalence of hyperlipidemia (P = 0.026), higher proportion of RIR (P = 0.015), a higher ratio of stroke subtypes of large artery atherosclerosis (P = 0.012), and high leukocyte counts (P < 0.001). The logistic regression analysis detected that RIR was associated with vulnerable plaques after adjusted for major confounding factors (OR 1.98, 95% CI 1.13-3.45, P = 0.016), especially in the large artery atherosclerosis subtype (OR 2.71, 95% CI 1.08-6.77, P = 0.034).
UNASSIGNED: In patients with ischemic stroke, RIR is associated with the vulnerability of carotid plaques, especially for those with the large artery atherosclerosis subtype. Therefore, further studies investigating the interventions to modulate inflammation in these patients may be warranted.
摘要：
炎症是动脉粥样硬化形成和最终斑块破裂的主要驱动因素。本研究旨在评估缺血性卒中患者残余炎症风险（RIR）与颈动脉易损斑块之间的关系。
■从2021年1月至2022年7月纳入急性缺血性卒中患者。他们被分为四组：仅RIR（LDL-C<2.6mmol/L和hsCRP≥2mg/L），仅残余胆固醇风险（RCR）（LDL-C≥2.6mmol/L和hsCRP<2mg/L），风险或残余胆固醇和炎症风险（RCIR）（LDL-C≥2.6mmol/L和hsCRP≥2mg/L），两者均无风险（LDL-C<2.6mmol/L和hsCRP<2mg/L）。确定易损斑块是否具有<35Hounsfield单位(HU)的低衰减斑块CT值和>1.1的重构指数,这表明正重构。
■在468名登记患者中，157（33.5％）被检测到有易损斑块。没有风险的患者比例，RIR,RCR,RCIR为32.9%，28.6%,18.8%,和19.7%，分别。易损斑块患者高脂血症患病率较高(P=0.026),RIR比例较高(P=0.015)，大动脉粥样硬化的卒中亚型比例较高（P=0.012），和高白细胞计数（P<0.001）。Logistic回归分析发现，在校正主要混杂因素后，RIR与易损斑块相关（OR1.98，95％CI1.13-3.45，P=0.016），尤其是大动脉粥样硬化亚型（OR2.71，95％CI1.08-6.77，P=0.034）。
■缺血性卒中患者，RIR与颈动脉斑块的易损性有关,尤其是大动脉粥样硬化亚型。因此,可能需要进一步的研究来调查调节这些患者炎症的干预措施.
■从2021年1月至2022年7月纳入急性缺血性卒中患者。他们被分为四组：仅RIR（LDL-C<2.6mmol/L和hsCRP≥2mg/L），仅残余胆固醇风险（RCR）（LDL-C≥2.6mmol/L和hsCRP<2mg/L），风险或残余胆固醇和炎症风险（RCIR）（LDL-C≥2.6mmol/L和hsCRP≥2mg/L），两者均无风险（LDL-C<2.6mmol/L和hsCRP<2mg/L）。确定易损斑块是否具有<35Hounsfield单位(HU)的低衰减斑块CT值和>1.1的重构指数,这表明正重构。
■在468名登记患者中，157（33.5％）被检测到有易损斑块。没有风险的患者比例，RIR,RCR,RCIR为32.9%，28.6%,18.8%,和19.7%，分别。易损斑块患者高脂血症患病率较高(P=0.026),RIR比例较高(P=0.015)，大动脉粥样硬化的卒中亚型比例较高（P=0.012），和高白细胞计数（P<0.001）。Logistic回归分析发现，在校正主要混杂因素后，RIR与易损斑块相关（OR1.98，95％CI1.13-3.45，P=0.016），尤其是大动脉粥样硬化亚型（OR2.71，95％CI1.08-6.77，P=0.034）。
■缺血性卒中患者，RIR与颈动脉斑块的易损性有关,尤其是大动脉粥样硬化亚型。因此,可能需要进一步的研究来调查调节这些患者炎症的干预措施.
