PDF(Pubmed)
Abstract：
UNASSIGNED: Musculoskeletal disorders could be associated with metabolic disorders that are common after kidney transplantation, which could reduce the quality of life of patients. The aim of this study was to assess the prevalence of both musculoskeletal and metabolic disorders in kidney transplant patients.
UNASSIGNED: MEDLINE, CINAHL, Cochrane Library, EMBASE and Web of Science were searched from their inception up to June 2023. DerSimonian and Laird random-effects method was used to calculate pooled prevalence estimates and their 95% confidence intervals (CIs).
UNASSIGNED: 21,879 kidney transplant recipients from 38 studies were analysed. The overall proportion of kidney transplant patients with musculoskeletal disorders was 27.2% (95% CI: 18.4-36.0), with low muscle strength (64.5%; 95% CI: 43.1-81.3) being the most common disorder. Otherwise, the overall proportion of kidney transplant patients with metabolic disorders was 37.6% (95% CI: 21.9-53.2), with hypovitaminosis D (81.8%; 95% CI: 67.2-90.8) being the most prevalent disorder.
UNASSIGNED: The most common musculoskeletal disorders were low muscle strength, femoral osteopenia, and low muscle mass. Hypovitaminosis D, hyperparathyroidism, and hyperuricemia were also the most common metabolic disorders. These disorders could be associated with poorer quality of life in kidney transplant recipients.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier [CRD42023449171].
UNASSIGNED: MEDLINE, CINAHL, Cochrane Library, EMBASE and Web of Science were searched from their inception up to June 2023. DerSimonian and Laird random-effects method was used to calculate pooled prevalence estimates and their 95% confidence intervals (CIs).
UNASSIGNED: 21,879 kidney transplant recipients from 38 studies were analysed. The overall proportion of kidney transplant patients with musculoskeletal disorders was 27.2% (95% CI: 18.4-36.0), with low muscle strength (64.5%; 95% CI: 43.1-81.3) being the most common disorder. Otherwise, the overall proportion of kidney transplant patients with metabolic disorders was 37.6% (95% CI: 21.9-53.2), with hypovitaminosis D (81.8%; 95% CI: 67.2-90.8) being the most prevalent disorder.
UNASSIGNED: The most common musculoskeletal disorders were low muscle strength, femoral osteopenia, and low muscle mass. Hypovitaminosis D, hyperparathyroidism, and hyperuricemia were also the most common metabolic disorders. These disorders could be associated with poorer quality of life in kidney transplant recipients.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier [CRD42023449171].
摘要：
■肌肉骨骼疾病可能与肾移植后常见的代谢紊乱有关，这可能会降低患者的生活质量。这项研究的目的是评估肾移植患者中肌肉骨骼和代谢紊乱的患病率。
■MEDLINE,CINAHL,科克伦图书馆,EMBASE和WebofScience从成立之初一直搜索到2023年6月。DerSimonian和Laird随机效应方法用于计算合并患病率估计值及其95％置信区间（CI）。
■分析了来自38项研究的21,879名肾移植受者。有肌肉骨骼疾患的肾移植患者的总比例为27.2%(95%CI:18.4-36.0),低肌肉力量（64.5％；95％CI：43.1-81.3）是最常见的疾病。否则,肾移植患者中代谢紊乱的总比例为37.6%(95%CI:21.9-53.2),维生素D缺乏症(81.8%;95%CI:67.2-90.8)是最常见的疾病。
■最常见的肌肉骨骼疾病是肌肉力量低下，股骨骨质减少,肌肉质量低。维生素D缺乏症,甲状旁腺功能亢进,高尿酸血症也是最常见的代谢紊乱.这些疾病可能与肾移植受者的生活质量较差有关。
■https://www.crd.约克。AC.英国/普华永道/，标识符[CRD42023449171]。
■MEDLINE,CINAHL,科克伦图书馆,EMBASE和WebofScience从成立之初一直搜索到2023年6月。DerSimonian和Laird随机效应方法用于计算合并患病率估计值及其95％置信区间（CI）。
■分析了来自38项研究的21,879名肾移植受者。有肌肉骨骼疾患的肾移植患者的总比例为27.2%(95%CI:18.4-36.0),低肌肉力量（64.5％；95％CI：43.1-81.3）是最常见的疾病。否则,肾移植患者中代谢紊乱的总比例为37.6%(95%CI:21.9-53.2),维生素D缺乏症(81.8%;95%CI:67.2-90.8)是最常见的疾病。
■最常见的肌肉骨骼疾病是肌肉力量低下，股骨骨质减少,肌肉质量低。维生素D缺乏症,甲状旁腺功能亢进,高尿酸血症也是最常见的代谢紊乱.这些疾病可能与肾移植受者的生活质量较差有关。
■https://www.crd.约克。AC.英国/普华永道/，标识符[CRD42023449171]。
