PDF(Pubmed)
Abstract：
UNASSIGNED: The association between malignancy risk and nodule size in indeterminate thyroid nodules (ITNs) remains controversial. Thus, we aimed to explore the impact of nodule size as a predictor of cancer in patients with ITNs.
UNASSIGNED: This cross-sectional study assessed 113 patients who underwent surgical intervention for ITNs, comparing two groups based on nodule size (≥4 or <4 cm). The correlation between nodule size and malignancy risk was examined. Other variables of interest included demographics, thyroid-stimulating hormone (TSH) levels, type of surgery, and ultrasound features.
UNASSIGNED: Of the 113 patients, 88.5% were aged <55 years, 76.1% were women, and 65.5% had nodules <4 cm. Mean nodule size was 3.4±2.3 cm. There was no significant correlation between malignancy risk and nodule size (P=0.55). An association was observed between <4 cm nodules and elevated TSH levels (P=0.03) and between ≥4 cm nodules and the presence of hypervascularity (P=0.04). Nodules <4 cm were more likely to have extrathyroidal extension, lymphovascular invasion, and positive margins than those ≥4 cm; however, this was not significant.
UNASSIGNED: Our findings showed no association between nodule size and malignancy risk, suggesting that size alone is not a predictor of cancer development. Further prospective studies are required to confirm these results.
UNASSIGNED: This cross-sectional study assessed 113 patients who underwent surgical intervention for ITNs, comparing two groups based on nodule size (≥4 or <4 cm). The correlation between nodule size and malignancy risk was examined. Other variables of interest included demographics, thyroid-stimulating hormone (TSH) levels, type of surgery, and ultrasound features.
UNASSIGNED: Of the 113 patients, 88.5% were aged <55 years, 76.1% were women, and 65.5% had nodules <4 cm. Mean nodule size was 3.4±2.3 cm. There was no significant correlation between malignancy risk and nodule size (P=0.55). An association was observed between <4 cm nodules and elevated TSH levels (P=0.03) and between ≥4 cm nodules and the presence of hypervascularity (P=0.04). Nodules <4 cm were more likely to have extrathyroidal extension, lymphovascular invasion, and positive margins than those ≥4 cm; however, this was not significant.
UNASSIGNED: Our findings showed no association between nodule size and malignancy risk, suggesting that size alone is not a predictor of cancer development. Further prospective studies are required to confirm these results.
摘要：
■在不确定的甲状腺结节（ITN）中，恶性风险与结节大小之间的关联仍存在争议。因此，我们旨在探讨结节大小作为ITN患者癌症预测因子的影响.
■这项横断面研究评估了113名接受ITN手术干预的患者，根据结节大小（≥4或<4cm）比较两组。检查了结节大小与恶性肿瘤风险之间的相关性。其他感兴趣的变量包括人口统计，促甲状腺激素(TSH)水平,手术类型,和超声特征。
■在113名患者中,88.5%的人年龄<55岁，76.1%是女性，65.5%的结节<4厘米。平均结节大小为3.4±2.3cm。恶性肿瘤风险与结节大小之间没有显着相关性（P=0.55）。在<4cm结节与TSH水平升高（P=0.03）之间以及在≥4cm结节与血管过多（P=0.04）之间观察到关联。结节<4厘米更可能有甲状腺外延伸，淋巴管浸润,和大于≥4厘米的阳性边缘；然而，这并不重要。
■我们的研究结果表明，结节大小与恶性肿瘤风险之间没有关联，这表明大小本身并不能预测癌症的发展。需要进一步的前瞻性研究来证实这些结果。
■这项横断面研究评估了113名接受ITN手术干预的患者，根据结节大小（≥4或<4cm）比较两组。检查了结节大小与恶性肿瘤风险之间的相关性。其他感兴趣的变量包括人口统计，促甲状腺激素(TSH)水平,手术类型,和超声特征。
■在113名患者中,88.5%的人年龄<55岁，76.1%是女性，65.5%的结节<4厘米。平均结节大小为3.4±2.3cm。恶性肿瘤风险与结节大小之间没有显着相关性（P=0.55）。在<4cm结节与TSH水平升高（P=0.03）之间以及在≥4cm结节与血管过多（P=0.04）之间观察到关联。结节<4厘米更可能有甲状腺外延伸，淋巴管浸润,和大于≥4厘米的阳性边缘；然而，这并不重要。
■我们的研究结果表明，结节大小与恶性肿瘤风险之间没有关联，这表明大小本身并不能预测癌症的发展。需要进一步的前瞻性研究来证实这些结果。
