Abstract：
Acquired amegakaryocytic thrombocytopenia (AATP) is an uncommon cause of severe thrombocytopenia with preserved cells of other lineages, which can present with severe bleeding episodes. We report a case of a 45-year-old male with seronegative arthritis who was diagnosed with idiopathic thrombocytopenic purpura (ITP) and was being treated with steroids for ITP. Despite aggressive treatment, the patient had persistently low levels of platelets. In view of persistent thrombocytopenia, bone marrow biopsy was done and was diagnosed as Acquired Amegakaryocytic Thrombocytopenia (AATP). Patient was successfully treated with cyclosporine. Correct identification of AATP is essential because it can lead to life threatening bleeding manifestations and advance into Aplastic anemia or MDS. How to cite this article: N AM, Rajanna AH, Kamath N. Acquired Amegakaryocytic Thrombocytopenia Misdiagnosed as Immune Thrombocytopenia in a Patient with Seronegative Arthritis: A Case Report. J Assoc Physicians India 2023;71(11):100-102.
摘要：
获得性变核细胞性血小板减少症（AATP）是严重血小板减少症的罕见原因，与其他谱系的保留细胞，可能会出现严重的出血事件。我们报告了一例45岁的男性血清阴性关节炎，被诊断为特发性血小板减少性紫癜（ITP），并正在接受类固醇治疗ITP。尽管积极治疗，患者的血小板水平持续较低.鉴于持续性血小板减少症，进行骨髓活检,诊断为获得性巨核细胞性血小板减少症(AATP).患者成功用环孢素治疗。正确识别AATP是必不可少的，因为它可能导致危及生命的出血表现并进展为再生障碍性贫血或MDS。如何引用这篇文章：NAM，RajannaAH,KamathN.获得性巨核细胞性血小板减少症误诊为血清阴性关节炎患者的免疫性血小板减少症：一例。J印度Assoc医师2023；71（11）：100-102。
