在阿尔茨海默病小鼠模型中 , 类杆菌抑制小胶质细胞清除 β 淀粉样蛋白并促进斑块沉积。
Mesh : Animals Microglia / metabolism drug effects Alzheimer Disease / metabolism microbiology pathology Amyloid beta-Peptides / metabolism Plaque, Amyloid / metabolism Disease Models, Animal Female Phagocytosis Mice Male Mice, Transgenic Bacteroides fragilis / metabolism Gastrointestinal Microbiome Humans Mice, Inbred C57BL Hippocampus / metabolism pathology
来 源:
DOI:10.1038/s41467-024-47683-w
PDF(Pubmed)