PDF(Pubmed)
Abstract：
Chemonucleolysis utilizing condoliase is a minimally invasive treatment for lumbar disc herniation (LDH) aimed at reducing intervertebral disc pressure and enhancing symptoms. In this study, lower limb pain was measured using the numeric rating scale (NRS) the day after treatment and 1 and 3 months after treatment. Prognostic factors were assessed, categorizing participants into an improvement group (I-group) for NRS lower limb pain scores of ≥3.5 and a non-improvement group (N-group) for scores of <3.5. This study included a total of 225 patients treated between April 2020 and March 2023. The mean age was 46.5 ± 16.5 years, with 151 males. The mean duration of illness was 6.2 ± 8.52 months. As of the day after treatment, 60 cases were classified into the I-group, 118 cases at 1 month after surgery, and 152 cases at 3 months after surgery. The disease duration before treatment was significantly shorter in the I-group at 1 (8.19 ± 8.74 [I-group] vs. 5.17 ± 8.04 [N-group] months) and 3 months (8.51 [I-group] ± 7.35 vs. 5.69 ± 8.87[N-group] months) after treatment. The comparison of baseline leg pain NRS shows a difference in leg pain NRS in the I-group when compared on the day after treatment (6.02 ± 2.64 [I-group] vs. 7.50 ± 1.79 [N-group]), 1 (5.13 ± 2.69 [I-group] vs. 7.58 ± 1.66 [N-group]), and 3 months (4.42 ± 2.70 [I-group] vs. 7.34 ± 1.77 [N-group]). Chemonucleolysis using condoliase for LDH can improve symptoms the day after treatment and can be a minimally invasive treatment to avoid surgery.
摘要：
利用condoliase的化学核溶解术是腰椎间盘突出症（LDH）的微创治疗方法，旨在降低椎间盘压力并增强症状。在这项研究中,使用数字评定量表(NRS)在治疗后第1天和治疗后1个月和3个月测量下肢疼痛.评估预后因素，将参与者分为NRS下肢疼痛评分≥3.5的改善组(I组)和<3.5的非改善组(N组).这项研究共纳入了2020年4月至2023年3月期间接受治疗的225名患者。平均年龄为46.5±16.5岁,男性151平均病程为6.2±8.52个月。治疗后的第二天，60例分为I组，118例术后1个月,术后3个月152例。I组治疗前病程明显短于1(8.19±8.74[I组]vs.5.17±8.04[N组]个月）和3个月（8.51[I组]±7.35vs.治疗后5.69±8.87[N组]个月）。基线腿部疼痛NRS的比较显示，在治疗后一天进行比较时，I组的腿部疼痛NRS存在差异（6.02±2.64[I组]与7.50±1.79[N组])，1（5.13±2.69[I-group]vs.7.58±1.66[N组])，和3个月（4.42±2.70[I组]vs.7.34±1.77[N组])。使用condoliase治疗LDH的化学核溶解术可以在治疗后的第二天改善症状，并且可以是避免手术的微创治疗方法。
