Abstract：
In recent years, an increase in the incidence of liver diseases has been reported all over the world. This study aims to comprehensively summarize and quantitatively analyze the existing evidence concerning the effectiveness of grape-derived products on liver enzymes through a systematic review and meta-analytic approach. PubMed, Scopus, Cochrane Library, and ISI Web of Science were comprehensively searched until January 2024. Articles that reported the effect of grape-derived products on serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels were included. Weighted mean differences (WMDs) were pooled using a random-effects model. Nine studies were included in the meta-analysis. The results revealed that grape-derived products did not significantly change the concentrations of ALT (WMD: -2.70 IU/L, 95% CI: -6.14 to 0.75, p = 0.12), and AST (WMD: -1.42 IU/L, 95% CI: -3.54 to 0.70, p = 0.18). However, a significant reduction was observed in serum ALP levels (WMD: -5.49 IU/L, 95% CI: -9.57 to -1.4, p = 0.008). The present findings suggest that grape-derived products positively influence serum ALP levels among adults. However, a more comprehensive decision necessitates additional studies.
摘要：
近年来,全世界都有肝病发病率上升的报道。本研究旨在通过系统评价和荟萃分析方法，全面总结和定量分析有关葡萄衍生产品对肝酶有效性的现有证据。PubMed,Scopus,科克伦图书馆,和ISIWebofScience进行了全面搜索，直到2024年1月。文章报道了葡萄衍生产品对血清天冬氨酸转氨酶（AST）的影响，丙氨酸氨基转移酶（ALT），包括碱性磷酸酶（ALP）水平。使用随机效应模型汇集加权平均差异(WMD)。9项研究纳入荟萃分析。结果表明，葡萄衍生产品没有显着改变ALT的浓度（WMD：-2.70IU/L，95%CI：-6.14至0.75，p=0.12），和AST（大规模杀伤性武器：-1.42IU/L，95%CI：-3.54至0.70，p=0.18）。然而,血清ALP水平显着降低（WMD：-5.49IU/L，95%CI：-9.57至-1.4，p=0.008）。本研究结果表明，葡萄衍生产品对成年人的血清ALP水平有积极影响。然而,更全面的决定需要更多的研究。
