Abstract：
Objective.This study aims to characterize radiological properties of selected additive manufacturing (AM) materials utilizing both material extrusion and vat photopolymerization technologies. Monochromatic synchrotron x-ray images and synchrotron treatment beam dosimetry were acquired at the hutch 3B and 2B of the Australian Synchrotron-Imaging and Medical Beamline.Approach.Eight energies from 30 keV up to 65 keV were used to acquire the attenuation coefficients of the AM materials. Comparison of theoretical, and experimental attenuation data of AM materials and standard solid water for MV linac was performed. Broad-beam dosimetry experiment through attenuated dose measurement and a Geant4 Monte Carlo simulation were done for the studied materials to investigate its attenuation properties specific for a 4 tesla wiggler field with varying synchrotron radiation beam qualities.Main results.Polylactic acid (PLA) plus matches attenuation coefficients of both soft tissue and brain tissue, while acrylonitrile butadiene styrene, Acrylonitrile styrene acrylate, and Draft resin have close equivalence to adipose tissue. Lastly, PLA, co-polyester plus, thermoplastic polyurethane, and White resins are promising substitute materials for breast tissue. For broad-beam experiment and simulation, many of the studied materials were able to simulate RMI457 Solid Water and bolus within ±10% for the three synchrotron beam qualities. These results are useful in fabricating phantoms for synchrotron and other related medical radiation applications such as orthovoltage treatments.Significance and conclusion.These 3D printing materials were studied as potential substitutes for selected tissues such as breast tissue, adipose tissue, soft-tissue, and brain tissue useful in fabricating 3D printed phantoms for synchrotron imaging, therapy, and orthovoltage applications. Fabricating customizable heterogeneous anthropomorphic phantoms (e.g. breast, head, thorax) and pre-clinical animal phantoms (e.g. rodents, canine) for synchrotron imaging and radiotherapy using AM can be done based on the results of this study.
摘要：
目的：本研究旨在利用材料挤出和大桶光聚合技术来表征选定的增材制造（AM）材料的放射学特性。单色同步加速器X射线图像和同步加速器治疗束剂量测定是在澳大利亚同步加速器成像和医疗束线（AS-IMBL）的hutch3B上获得的。
方法:使用从30keV到65keV的八种能量来获取AM材料的衰减系数。理论比较，并进行了AM材料和MV直线加速器标准固体水的实验衰减数据。对所研究的材料进行了通过衰减剂量测量和Geant4蒙特卡罗模拟的宽束剂量测定实验，以研究其特定于具有不同同步加速器辐射束质量的4特斯拉摇摆器场的衰减特性。
主要结果:PLAplus匹配软组织和脑组织的衰减系数,而ABS,ASA,和牵伸树脂与脂肪组织具有接近的等效性。最后,PLA,CPEplus,TPU,和白色树脂是有前途的乳腺组织的替代材料。对于宽光束实验和模拟，许多研究的材料能够模拟RMI457SolidWater和Bolus在三种同步加速器光束质量的+/-10％以内。这些结果可用于制造用于同步加速器和其他相关医学辐射应用的体模，例如正电压治疗。＆＃xD;意义和结论：研究了这些3D打印材料作为乳腺组织等选定组织的潜在替代品，脂肪组织,软组织,和用于制造用于同步加速器成像的3D打印体模的脑组织，治疗,和正电压应用。制作可定制的异质拟人化体模(例如，乳房、头部,胸部)和临床前动物模型(例如啮齿动物，犬）使用AM进行同步加速器成像和放射治疗可以根据这项研究的结果进行。
