Abstract：
BACKGROUND: Breast cancer is the most common cancer in women which can be cured in most individuals with early-stage non-metastatic disease. Imbalance in estrogen signaling pathways and propagating levels of estrogens has important roles in breast cancer development. Targeting the estrogen receptor signaling pathway is linked to breast cancer treatment. Royal jelly is one of the bee products containing 10-hydroxy-2-decenoic acid, a structure similar to mammalian estrogen, allowing it to attach to estrogen receptors. It is considered as a general tonic and immunomodulator which may be helpful in reducing the side effects of cancer treatments. Currently, there are controversial data regarding the pros and cons of royal jelly in cancer. Here we provide an overview of the effects of royal jelly on sex hormones and its possible role in breast cancer.
METHODS: Electronic databases including PubMed, Scopus, and Web of Science were searched with the search terms royal jelly, cancer, and sexual hormones. All preclinical and clinical studies regarding the hormonal effects of royal jelly were included.
RESULTS: According to the collected preclinical data, consumption of royal jelly at daily doses below 200 mg/kg can be useful to decrease the risk of breast cancer since it reduces the serum level of estrogen; whereas increases progesterone, which subsequently decreases the expression of ERs on the ER-positive cells.
CONCLUSIONS: Future clinical studies are essential to confirm the safe dose of royal jelly as an adjuvant therapy in breast cancer.
METHODS: Electronic databases including PubMed, Scopus, and Web of Science were searched with the search terms royal jelly, cancer, and sexual hormones. All preclinical and clinical studies regarding the hormonal effects of royal jelly were included.
RESULTS: According to the collected preclinical data, consumption of royal jelly at daily doses below 200 mg/kg can be useful to decrease the risk of breast cancer since it reduces the serum level of estrogen; whereas increases progesterone, which subsequently decreases the expression of ERs on the ER-positive cells.
CONCLUSIONS: Future clinical studies are essential to confirm the safe dose of royal jelly as an adjuvant therapy in breast cancer.
摘要：
背景：乳腺癌是女性中最常见的癌症，在大多数患有早期非转移性疾病的个体中可以治愈。雌激素信号通路的失衡和雌激素水平的传播在乳腺癌的发展中具有重要作用。靶向雌激素受体信号通路与乳腺癌治疗有关。蜂王浆是含有10-羟基-2-癸烯酸的蜂产品之一，一种类似于哺乳动物雌激素的结构，让它附着在雌激素受体上。它被认为是一种一般的滋补和免疫调节剂，可能有助于减少癌症治疗的副作用。目前,关于蜂王浆在癌症中的利弊有争议的数据。在这里，我们概述了蜂王浆对性激素的影响及其在乳腺癌中的可能作用。
方法：电子数据库，包括PubMed，Scopus,用搜索词蜂王浆搜索了WebofScience，癌症,和性激素。包括有关蜂王浆激素作用的所有临床前和临床研究。
结果：根据收集的临床前数据，每日剂量低于200mg/kg的蜂王浆消费可用于降低患乳腺癌的风险，因为它降低了雌激素的血清水平;而增加孕激素，随后降低ER阳性细胞上ER的表达。
结论：未来的临床研究对于确认蜂王浆作为乳腺癌辅助治疗的安全剂量至关重要。
方法：电子数据库，包括PubMed，Scopus,用搜索词蜂王浆搜索了WebofScience，癌症,和性激素。包括有关蜂王浆激素作用的所有临床前和临床研究。
结果：根据收集的临床前数据，每日剂量低于200mg/kg的蜂王浆消费可用于降低患乳腺癌的风险，因为它降低了雌激素的血清水平;而增加孕激素，随后降低ER阳性细胞上ER的表达。
结论：未来的临床研究对于确认蜂王浆作为乳腺癌辅助治疗的安全剂量至关重要。
