PDF(Pubmed)
Abstract：
OBJECTIVE: To systematically review the reported cases of Creutzfeldt-Jakob disease (CJD) in Iran.
METHODS: A comprehensive literature review of CJD cases in Iran was undertaken using the PubMed®, Scopus® and Google Scholar databases. In addition, the Iranian database MagIran was searched for Persian language reports. Case selection used the following criteria: (i) patients of Iranian origin; (ii) publication in peer-reviewed journals or reputable medical databases; (iii) a definitive diagnosis of CJD based on established diagnostic criteria.
RESULTS: Thirteen cases from twelve reports were included in this systematic review. The majority of the cases were female (11 of 13; 84.6%). The mean ± SD age of patients at hospital admission was 59.38 ± 7.44 years. The findings of the case review suggested that the prevalence of CJD in Iran is not fully established. CJD may be misdiagnosed alongside other clinical signs. The most prevalent early indications of the disease were psychiatric and neurological in nature. A considerable delay in diagnosis was observed in some cases and there was a shortage of brain autopsy records.
CONCLUSIONS: Efforts to improve diagnostic capabilities, promote awareness and establish monitoring systems are necessary for managing the challenges of providing an early diagnosis of CJD in Iran.
METHODS: A comprehensive literature review of CJD cases in Iran was undertaken using the PubMed®, Scopus® and Google Scholar databases. In addition, the Iranian database MagIran was searched for Persian language reports. Case selection used the following criteria: (i) patients of Iranian origin; (ii) publication in peer-reviewed journals or reputable medical databases; (iii) a definitive diagnosis of CJD based on established diagnostic criteria.
RESULTS: Thirteen cases from twelve reports were included in this systematic review. The majority of the cases were female (11 of 13; 84.6%). The mean ± SD age of patients at hospital admission was 59.38 ± 7.44 years. The findings of the case review suggested that the prevalence of CJD in Iran is not fully established. CJD may be misdiagnosed alongside other clinical signs. The most prevalent early indications of the disease were psychiatric and neurological in nature. A considerable delay in diagnosis was observed in some cases and there was a shortage of brain autopsy records.
CONCLUSIONS: Efforts to improve diagnostic capabilities, promote awareness and establish monitoring systems are necessary for managing the challenges of providing an early diagnosis of CJD in Iran.
摘要：
目的：系统回顾伊朗报道的克雅氏病（CJD）病例。
方法：使用PubMed®对伊朗的CJD病例进行了全面的文献综述，Scopus®和GoogleScholar数据库。此外,搜索了伊朗数据库MagIran的波斯语报告。病例选择使用以下标准：（i）伊朗血统的患者；（ii）在同行评审的期刊或信誉良好的医学数据库中发表；（iii）根据已建立的诊断标准对CJD进行明确诊断。
结果：本系统综述包括12例报告中的13例病例。大多数病例为女性（13人中有11人；84.6%）。入院时患者的平均±SD年龄为59.38±7.44岁。病例审查的结果表明，伊朗的CJD患病率尚未完全确定。CJD可能与其他临床体征一起被误诊。该疾病最普遍的早期适应症本质上是精神病学和神经学。在某些情况下，发现诊断有相当大的延迟，并且缺乏脑部尸检记录。
结论：努力提高诊断能力，提高认识和建立监测系统对于管理在伊朗提供CJD早期诊断的挑战是必要的。
方法：使用PubMed®对伊朗的CJD病例进行了全面的文献综述，Scopus®和GoogleScholar数据库。此外,搜索了伊朗数据库MagIran的波斯语报告。病例选择使用以下标准：（i）伊朗血统的患者；（ii）在同行评审的期刊或信誉良好的医学数据库中发表；（iii）根据已建立的诊断标准对CJD进行明确诊断。
结果：本系统综述包括12例报告中的13例病例。大多数病例为女性（13人中有11人；84.6%）。入院时患者的平均±SD年龄为59.38±7.44岁。病例审查的结果表明，伊朗的CJD患病率尚未完全确定。CJD可能与其他临床体征一起被误诊。该疾病最普遍的早期适应症本质上是精神病学和神经学。在某些情况下，发现诊断有相当大的延迟，并且缺乏脑部尸检记录。
结论：努力提高诊断能力，提高认识和建立监测系统对于管理在伊朗提供CJD早期诊断的挑战是必要的。
