PDF(Pubmed)
Abstract：
Lipopolysaccharide (LPS) is widely used to establish various animal models, including models of acute lung injury, cardiomyocyte damage, and acute kidney injury. Currently, there is no consensus on the diagnosis and treatment of LPS-induced disease. We herein present a case series of four patients who developed dose-dependent multi-organ injury, including acute lung injury and acute kidney injury, after inhaling LPS gas in a sealed room. These patients exhibited varying degrees of multi-organ injury characterized by inflammatory cell infiltration and secretion of proinflammatory cytokines. One patient showed progressive symptoms even with active treatment, leading to mild pulmonary fibrosis. This study emphasizes the importance of early diagnosis and treatment of significant LPS exposure and suggests personalized treatment approaches for managing LPS poisoning.
摘要：
脂多糖(LPS)被广泛用于建立各种动物模型,包括急性肺损伤模型，心肌细胞损伤，和急性肾损伤。目前,关于LPS引起的疾病的诊断和治疗尚无共识。我们在此介绍了一系列病例，包括四名发生剂量依赖性多器官损伤的患者，包括急性肺损伤和急性肾损伤,在密封室内吸入LPS气体后。这些患者表现出不同程度的多器官损伤，其特征是炎症细胞浸润和促炎细胞因子的分泌。一名患者即使经过积极治疗也表现出进行性症状，导致轻度肺纤维化.这项研究强调了早期诊断和治疗大量LPS暴露的重要性，并提出了管理LPS中毒的个性化治疗方法。
