Abstract：
OBJECTIVE: To determine the prevalence of human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) across Asian countries, focusing on South and Southeast Asia.
METHODS: A systematic search of four databases-MEDLINE/PubMed, EMBASE, Scopus, and ProQuest-was conducted to identify observational studies published between January 2013 and December 2023. The pooled prevalence of HPV was estimated using random-effects models, and subgroup analysis was performed to investigate the source of heterogeneity.
RESULTS: A total of 77 studies were included, comprising 7289 OSCC cases from 11 countries. The pooled HPV prevalence in OSCC was 23.1% (95% CI 17.9-28.7, I2 = 96.7%). South Asia had the highest prevalence (27.1%), followed by East Asia (19.4%), and Southeast Asia (16.7%). Two subtypes were commonly reported: HPV-16 (9.1%) and HPV-18 (5.1%). Anatomical subsites, buccal mucosa (34.0%), and floor of the mouth (33.2%) had similar ranges of HPV prevalence. All studies exhibited a high degree of heterogeneity, with the OSCC location and risk of bias identified as potential sources of heterogeneity.
CONCLUSIONS: Due to the high HPV prevalence in OSCC in Asia, HPV detection in routine pathology practice is recommended. Future studies should be conducted in multicentre settings using similar HPV detection methods and reporting detailed demographic and clinical information on oral sub-sites.
METHODS: A systematic search of four databases-MEDLINE/PubMed, EMBASE, Scopus, and ProQuest-was conducted to identify observational studies published between January 2013 and December 2023. The pooled prevalence of HPV was estimated using random-effects models, and subgroup analysis was performed to investigate the source of heterogeneity.
RESULTS: A total of 77 studies were included, comprising 7289 OSCC cases from 11 countries. The pooled HPV prevalence in OSCC was 23.1% (95% CI 17.9-28.7, I2 = 96.7%). South Asia had the highest prevalence (27.1%), followed by East Asia (19.4%), and Southeast Asia (16.7%). Two subtypes were commonly reported: HPV-16 (9.1%) and HPV-18 (5.1%). Anatomical subsites, buccal mucosa (34.0%), and floor of the mouth (33.2%) had similar ranges of HPV prevalence. All studies exhibited a high degree of heterogeneity, with the OSCC location and risk of bias identified as potential sources of heterogeneity.
CONCLUSIONS: Due to the high HPV prevalence in OSCC in Asia, HPV detection in routine pathology practice is recommended. Future studies should be conducted in multicentre settings using similar HPV detection methods and reporting detailed demographic and clinical information on oral sub-sites.
摘要：
目的：确定亚洲国家口腔鳞状细胞癌（OSCC）中人乳头瘤病毒（HPV）的患病率，专注于南亚和东南亚。
方法：对四个数据库的系统搜索-MEDLINE/PubMed，EMBASE,Scopus,和ProQuest-进行是为了确定2013年1月至2023年12月之间发表的观察性研究。使用随机效应模型估计HPV的合并患病率，并进行亚组分析以调查异质性的来源。
结果：共纳入77项研究，包括来自11个国家的7289例OSCC病例。OSCC中合并的HPV患病率为23.1％（95％CI17.9-28.7，I2=96.7％）。南亚的患病率最高(27.1%),其次是东亚(19.4%)，和东南亚（16.7%）。通常报道两种亚型：HPV-16（9.1％）和HPV-18（5.1％）。解剖学亚位点,颊粘膜（34.0%），和口底(33.2%)的HPV患病率范围相似.所有研究都表现出高度的异质性，将OSCC的位置和偏倚风险确定为异质性的潜在来源。
结论：由于亚洲OSCC中HPV的高患病率，建议在常规病理实践中进行HPV检测。未来的研究应该在多中心环境中进行，使用类似的HPV检测方法，并报告详细的人口统计学和临床信息。
方法：对四个数据库的系统搜索-MEDLINE/PubMed，EMBASE,Scopus,和ProQuest-进行是为了确定2013年1月至2023年12月之间发表的观察性研究。使用随机效应模型估计HPV的合并患病率，并进行亚组分析以调查异质性的来源。
结果：共纳入77项研究，包括来自11个国家的7289例OSCC病例。OSCC中合并的HPV患病率为23.1％（95％CI17.9-28.7，I2=96.7％）。南亚的患病率最高(27.1%),其次是东亚(19.4%)，和东南亚（16.7%）。通常报道两种亚型：HPV-16（9.1％）和HPV-18（5.1％）。解剖学亚位点,颊粘膜（34.0%），和口底(33.2%)的HPV患病率范围相似.所有研究都表现出高度的异质性，将OSCC的位置和偏倚风险确定为异质性的潜在来源。
结论：由于亚洲OSCC中HPV的高患病率，建议在常规病理实践中进行HPV检测。未来的研究应该在多中心环境中进行，使用类似的HPV检测方法，并报告详细的人口统计学和临床信息。
