Abstract：
The intensification of the aging population is often accompanied by an increase in agerelated diseases, which impair the quality of life of the elderly. The characteristic feature of aging is progressive physiological decline, which is the largest cause of human pathology and death worldwide. However, natural aging interacts in exceptionally complex ways within and between organs, but its underlying mechanisms are still poorly understood. Long non-coding RNA (lncRNA) is a type of noncoding RNA that exceeds 200 nucleotides in length and does not possess protein-coding ability. It plays a crucial role in the occurrence and development of diseases. ANRIL, also known as CDKN2B-AS1, is an antisense ncRNA located at the INK4 site. It can play a crucial role in agerelated disease progression by regulating single nucleotide polymorphism, histone modifications, or post-transcriptional modifications (such as RNA stability and microRNA), such as cardiovascular disease, diabetes, tumor, arthritis, and osteoporosis. Therefore, a deeper understanding of the molecular mechanisms of lncRNA ANRIL in age-related diseases will help provide new diagnostic and therapeutic targets for clinical practice.
摘要：
人口老龄化的加剧往往伴随着老年相关疾病的增加,这损害了老年人的生活质量。衰老的特征是进行性生理衰退，这是全世界人类病理和死亡的最大原因。然而,自然衰老在器官内部和器官之间以异常复杂的方式相互作用，但其潜在机制仍然知之甚少。长链非编码RNA（lncRNA）是一种长度超过200个核苷酸的非编码RNA，不具有蛋白质编码能力。它在疾病的发生发展中起着至关重要的作用。ANRIL,也称为CDKN2B-AS1,是位于INK4位点的反义ncRNA。它可以通过调节单核苷酸多态性在疾病进展中发挥关键作用，组蛋白修饰，或转录后修饰（如RNA稳定性和microRNA），比如心血管疾病，糖尿病,肿瘤，关节炎,和骨质疏松症。因此,深入了解lncRNAANRIL在年龄相关疾病中的分子机制,将有助于为临床实践提供新的诊断和治疗靶点.
