PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetes mellitus (DM) is a category of metabolic conditions affecting about 5% of people worldwide. High mortality associated with DM is mostly due to its severe clinical complications, including diabetic nephropathy, retinopathy, neuropathy, and cardiomyopathy. Resveratrol (RSV) is a natural, biologically active polyphenol known to have various health-promoting effects in animal models and humans.
UNASSIGNED: In this review, we have reviewed the preventive and therapeutic role of RSV on diabetes complications with emphasis on its molecular mechanisms of action.
UNASSIGNED: To prepare this review, all the basic and clinical available literatures regarding this topic were gathered through electronic databases, including PubMed, Web of Science, Scopus, and Google Scholar. Therefore, we summarized previous studies that have evaluated the effects of RSV on diabetic complications and their mechanisms. Only English language studies published up to January 2023 were included in this review.
UNASSIGNED: RSV improves glucose homeostasis, decreases insulin resistance, induces autophagy, regulates lipid metabolism, protects pancreatic β-cells, ameliorates metabolic disorders, and increases the GLUT4 expression. These effects induced by RSV are strongly associated with ability of this polyphenol agent to elevation expression/activity of AMP-activated protein kinase and Sirtuin 1 in various organs of diabetic subjects, which leads to prevention and therapy of diabetic complications. In addition, antioxidant and anti-inflammatory properties of RSV were reported to be involved in its action in diabetic complications, such as retinopathy and nephropathy.
UNASSIGNED: RSV is a promising compound for improving diabetic complications. However, the exact antidiabetic mechanisms of RSV need to be further investigated.
UNASSIGNED: In this review, we have reviewed the preventive and therapeutic role of RSV on diabetes complications with emphasis on its molecular mechanisms of action.
UNASSIGNED: To prepare this review, all the basic and clinical available literatures regarding this topic were gathered through electronic databases, including PubMed, Web of Science, Scopus, and Google Scholar. Therefore, we summarized previous studies that have evaluated the effects of RSV on diabetic complications and their mechanisms. Only English language studies published up to January 2023 were included in this review.
UNASSIGNED: RSV improves glucose homeostasis, decreases insulin resistance, induces autophagy, regulates lipid metabolism, protects pancreatic β-cells, ameliorates metabolic disorders, and increases the GLUT4 expression. These effects induced by RSV are strongly associated with ability of this polyphenol agent to elevation expression/activity of AMP-activated protein kinase and Sirtuin 1 in various organs of diabetic subjects, which leads to prevention and therapy of diabetic complications. In addition, antioxidant and anti-inflammatory properties of RSV were reported to be involved in its action in diabetic complications, such as retinopathy and nephropathy.
UNASSIGNED: RSV is a promising compound for improving diabetic complications. However, the exact antidiabetic mechanisms of RSV need to be further investigated.
摘要：
■糖尿病（DM）是一类代谢疾病，影响全球约5％的人。与DM相关的高死亡率主要是由于其严重的临床并发症。包括糖尿病肾病,视网膜病变,神经病,和心肌病。白藜芦醇（RSV）是一种天然，已知生物活性多酚在动物模型和人类中具有各种健康促进作用。
■在这篇评论中，我们综述了RSV在糖尿病并发症中的预防和治疗作用,重点阐述了RSV的分子作用机制.
■为了准备这次审查，所有关于这个主题的基础和临床可用文献都是通过电子数据库收集的，包括PubMed,WebofScience,Scopus,谷歌学者。因此,我们总结了以前评估RSV对糖尿病并发症的影响及其机制的研究。本评论仅包括截至2023年1月发表的英语语言研究。
■RSV改善葡萄糖稳态，降低胰岛素抵抗，诱导自噬，调节脂质代谢，保护胰腺β细胞，改善代谢紊乱，并增加GLUT4表达。RSV诱导的这些作用与这种多酚试剂在糖尿病受试者的各种器官中升高AMP激活的蛋白激酶和Sirtuin1的表达/活性的能力密切相关。导致糖尿病并发症的预防和治疗。此外,据报道，RSV的抗氧化和抗炎特性参与其在糖尿病并发症中的作用，如视网膜病变和肾病。
■RSV是改善糖尿病并发症的有前途的化合物。然而,RSV确切的抗糖尿病机制有待进一步研究.
■在这篇评论中，我们综述了RSV在糖尿病并发症中的预防和治疗作用,重点阐述了RSV的分子作用机制.
■为了准备这次审查，所有关于这个主题的基础和临床可用文献都是通过电子数据库收集的，包括PubMed,WebofScience,Scopus,谷歌学者。因此,我们总结了以前评估RSV对糖尿病并发症的影响及其机制的研究。本评论仅包括截至2023年1月发表的英语语言研究。
■RSV改善葡萄糖稳态，降低胰岛素抵抗，诱导自噬，调节脂质代谢，保护胰腺β细胞，改善代谢紊乱，并增加GLUT4表达。RSV诱导的这些作用与这种多酚试剂在糖尿病受试者的各种器官中升高AMP激活的蛋白激酶和Sirtuin1的表达/活性的能力密切相关。导致糖尿病并发症的预防和治疗。此外,据报道，RSV的抗氧化和抗炎特性参与其在糖尿病并发症中的作用，如视网膜病变和肾病。
■RSV是改善糖尿病并发症的有前途的化合物。然而,RSV确切的抗糖尿病机制有待进一步研究.
