PDF(Pubmed)
Abstract：
A nanoparticle-drug delivery system against Staphylococcus aureus, especially Methicillin-resistant staphylococcus aureus, has been recently proposed as an alternative pathway therapy. Methicillin-resistant staphylococcus aureus is resistance to many antibiotics, making it a a threat to human life, especially for older and immunocompromised people. Treatment of Multidrug-resistant staphylococcus aureus is considered an urgent need. A variety of kinds of nanoparticle-drug delivery systems with different compositions, and biological properties have been extensively investigated against Staphylococcus aureus. This review summarizes the novel nanoparticle-drug delivery systems against Staphylococcus aureus. These nanoparticle-drug delivery systems could reduce antibiotic resistance and minimize side effects of the antibiotics. Also, they can deliver a high concentration of the drugs and eliminate the bacteria in a specific and targeted site of infection. Despite these benefits of nanoparticle-drug delivery systems, the cytotoxicity, stress oxidative, genotoxicity, and inflammation that may occur in vivo and in vitro should not be ignored. Therefore, we need a better knowledge of the pharmacological properties and safety concerns of nanoparticle-drug delivery systems. The limitations of each nanoparticle-drug delivery system with high therapeutic potential have to be considered for further design.
摘要：
一种针对金黄色葡萄球菌的纳米颗粒药物递送系统，尤其是耐甲氧西林金黄色葡萄球菌，最近被提议作为替代途径疗法。耐甲氧西林金黄色葡萄球菌对多种抗生素耐药,使其成为对人类生命的威胁，尤其是老年人和免疫功能低下的人。多重耐药金黄色葡萄球菌的治疗被认为是迫切需要的。具有不同组成的各种纳米颗粒-药物递送系统，以及针对金黄色葡萄球菌的生物学特性已被广泛研究。本文综述了针对金黄色葡萄球菌的新型纳米颗粒给药系统。这些纳米颗粒-药物递送系统可以降低抗生素耐药性并最小化抗生素的副作用。此外，它们可以提供高浓度的药物，并消除特定和目标感染部位的细菌。尽管纳米颗粒药物递送系统有这些好处，细胞毒性，氧化应激，遗传毒性，体内和体外可能发生的炎症不容忽视。因此,我们需要更好地了解纳米颗粒给药系统的药理学特性和安全性问题.具有高治疗潜力的每种纳米颗粒-药物递送系统的局限性必须被考虑用于进一步设计。
