PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate the effect of early vascular embolization for intracranial aneurysms and the effect of matrix metalloproteinase-9 (MMP-9) and nuclear factor-kappa B (NF-κB) on nerve function.
METHODS: This is a retrospective analysis study. A total of 90 patients with intracranial aneurysms admitted to our hospital from January 2017 to December 2021 were selected as research subjects. The patients were divided into a control group (n=47) and an observation group (n=43) according to different embolization timing. Both groups were treated with vascular embolization, the observation group received vascular embolization within 72 h after onset, while the control group received vascular embolization after 72 h. In addition, both groups were given clopidogrel bisulfate tablets and enteric-coated aspirin tablets from the day after operation for 3 months. The embolization at 3 months after operation, the occurrence of complications, the daily activities and neurological function before and 3 months after operation, serum levels of MMP-9 and NF-κB, the protein expression of MMP-9 and NF-κB, and the prognosis at 3 months after operation were compared between the two groups.
RESULTS: The complete embolization rate (90.70%) in observation group was higher than that of the control group (72.34%) at 3 months after operation (P<0.05). The postoperative complications in the observation group (9.30%) were lower than those of the control group (27.66%) (P<0.05). The improvement in Modified Barthel index score, as well as serum levels of MMP-9 and NF-κB were better in the observation group than those of the control group 3 months after operation (P<0.05). The prognosis of patients in the observation group was better than those of the control group 3 months after operation (P<0.05).
CONCLUSIONS: Early vascular embolization is an effective approach for intracranial aneurysm. It helps improve patients\' neurological function, and reduce their serum and protein levels of both MMP-9 and NF-κB, thereby leading to favorable prognosis.
METHODS: This is a retrospective analysis study. A total of 90 patients with intracranial aneurysms admitted to our hospital from January 2017 to December 2021 were selected as research subjects. The patients were divided into a control group (n=47) and an observation group (n=43) according to different embolization timing. Both groups were treated with vascular embolization, the observation group received vascular embolization within 72 h after onset, while the control group received vascular embolization after 72 h. In addition, both groups were given clopidogrel bisulfate tablets and enteric-coated aspirin tablets from the day after operation for 3 months. The embolization at 3 months after operation, the occurrence of complications, the daily activities and neurological function before and 3 months after operation, serum levels of MMP-9 and NF-κB, the protein expression of MMP-9 and NF-κB, and the prognosis at 3 months after operation were compared between the two groups.
RESULTS: The complete embolization rate (90.70%) in observation group was higher than that of the control group (72.34%) at 3 months after operation (P<0.05). The postoperative complications in the observation group (9.30%) were lower than those of the control group (27.66%) (P<0.05). The improvement in Modified Barthel index score, as well as serum levels of MMP-9 and NF-κB were better in the observation group than those of the control group 3 months after operation (P<0.05). The prognosis of patients in the observation group was better than those of the control group 3 months after operation (P<0.05).
CONCLUSIONS: Early vascular embolization is an effective approach for intracranial aneurysm. It helps improve patients\' neurological function, and reduce their serum and protein levels of both MMP-9 and NF-κB, thereby leading to favorable prognosis.
摘要：
目的：探讨颅内动脉瘤早期血管栓塞的疗效及基质金属蛋白酶-9(MMP-9)和核因子-κB(NF-κB)对神经功能的影响。
方法：这是一项回顾性分析研究。选取2017年1月至2021年12月我院收治的90例颅内动脉瘤患者作为研究对象。根据栓塞时机不同将患者分为对照组(n=47)和观察组(n=43)。两组均采用血管栓塞治疗,观察组在发病后72h内接受血管栓塞治疗，而对照组在72h后接受血管栓塞治疗。此外，两组均从术后次日起给予硫酸氢氯吡格雷片和阿司匹林肠溶片治疗3个月.术后3个月栓塞,并发症的发生，术前、术后3个月的日常活动及神经功能,血清MMP-9和NF-κB水平,MMP-9和NF-κB的蛋白表达,比较两组患者术后3个月的预后。
结果：术后3个月观察组完全栓塞率(90.70%)高于对照组(72.34%)(P<0.05)。观察组术后并发症发生率(9.30%)低于对照组(27.66%)(P<0.05)。改良Barthel指数评分的改善，术后3个月,观察组血清MMP-9和NF-κB水平均优于对照组(P<0.05)。观察组患者术后3个月预后优于对照组(P<0.05)。
结论：早期血管栓塞是治疗颅内动脉瘤的有效方法。它有助于改善病人的神经功能,并降低MMP-9和NF-κB的血清和蛋白质水平，从而导致良好的预后。
方法：这是一项回顾性分析研究。选取2017年1月至2021年12月我院收治的90例颅内动脉瘤患者作为研究对象。根据栓塞时机不同将患者分为对照组(n=47)和观察组(n=43)。两组均采用血管栓塞治疗,观察组在发病后72h内接受血管栓塞治疗，而对照组在72h后接受血管栓塞治疗。此外，两组均从术后次日起给予硫酸氢氯吡格雷片和阿司匹林肠溶片治疗3个月.术后3个月栓塞,并发症的发生，术前、术后3个月的日常活动及神经功能,血清MMP-9和NF-κB水平,MMP-9和NF-κB的蛋白表达,比较两组患者术后3个月的预后。
结果：术后3个月观察组完全栓塞率(90.70%)高于对照组(72.34%)(P<0.05)。观察组术后并发症发生率(9.30%)低于对照组(27.66%)(P<0.05)。改良Barthel指数评分的改善，术后3个月,观察组血清MMP-9和NF-κB水平均优于对照组(P<0.05)。观察组患者术后3个月预后优于对照组(P<0.05)。
结论：早期血管栓塞是治疗颅内动脉瘤的有效方法。它有助于改善病人的神经功能,并降低MMP-9和NF-κB的血清和蛋白质水平，从而导致良好的预后。
