PDF(Pubmed)
Abstract：
Scirrhous hepatocellular carcinoma (S-HCC) represents an uncommon subtype of HCC. During radiological evaluation this unique subtype is frequently mistaken as cholangiocarcinoma, fibrolamellar HCC, or metastatic adenocarcinoma. Here, we present the case of a 50-year-old woman with a large hepatic mass. A triple-phase computed tomography of the liver revealed an arterial enhancing lesion without portovenous washout at hepatic segment 4a/8. The liver biopsy showed hepatocellular characteristics and was positive for Hep Par 1, CK7, CK19, Arginase 1 and CEA, indicating atypical S-HCC. This patient had achieved tumor control with combined treatment with atezolizumab plus bevacizumab and was then treated with lenvatinib after tumor progression. The patient died 15 months after the initial diagnosis.
摘要：
硬性肝细胞癌（S-HCC）是HCC的一种罕见亚型。在放射学评估中，这种独特的亚型经常被误认为是胆管癌。纤维板层肝癌，或转移性腺癌。这里,我们介绍了一个50岁的女性，肝脏肿块很大。肝脏的三相计算机断层扫描显示，肝4a/8段无门静脉冲洗的动脉增强病变。肝活检显示肝细胞特征，HepPar1、CK7、CK19、精氨酸酶1和CEA阳性，提示非典型S-HCC。该患者通过阿特珠单抗加贝伐单抗联合治疗实现了肿瘤控制，然后在肿瘤进展后用乐伐替尼治疗。患者在最初诊断后15个月死亡。
