PDF(Pubmed)
Abstract：
UNASSIGNED: Adolescent idiopathic scoliosis (AIS) is a prevalent spinal disorder that can potentially influence bone mineral density (BMD), thereby increasing the susceptibility to osteoporosis and fractures. Early identification of reduced bone mass in AIS patients is crucial for clinicians to develop effective preventive strategies against fractures. This study aims to elucidate the correlation between BMD, as measured by quantitative computed tomography (QCT), and various clinical parameters in AIS, including the Cobb angle, vertebral rotation, and the Risser sign. By revealing the potential influences of these factors on BMD, our findings aim to assist clinicians in making informed and timely decisions regarding AIS management, particularly in situations where QCT is unavailable.
UNASSIGNED: A cross-sectional study was conducted on 129 adolescents with AIS who were enrolled at The Third People\'s Hospital of Chengdu, Sichuan, China, between 2021 and 2023. QCT was employed to assess BMD and vertebral rotation. The Cobb angle and Risser sign were determined through radiographic evaluation, while anthropometric and biochemical data were also collected. Statistical analyses, including Pearson and Spearman rank correlation and regression models, were used to investigate the associations between BMD and clinical measures.
UNASSIGNED: A significant negative correlation was found between BMD and Cobb angle (coefficient =-0.663; P<0.001), as well as between BMD and vertebral rotation angle (coefficient =-0.442; P<0.001) in patients with AIS. BMD was positively correlated with increased height (coefficient =0.355; P<0.001) and BMI (coefficient =0.199; P=0.02). A significant association was detected between BMD and the Risser sign (P=0.002). No significant sex-based differences in BMD were observed (P=0.052). No significant correlations were observed between BMD and levels of potassium (K), calcium (Ca), inorganic phosphate (P), and iron (Fe) (P>0.05 all). The binary logistic regression analysis identified Cobb angle as a risk factor of lower BMD presence in AIS patients (coefficient =0.072; OR=1.075; P<0.001). Furthermore, the receiver operating characteristic (ROC) analysis of the combined model for predicting low BMD in AIS patients yielded an area under the curve (AUC) value of 0.900, with an optimal threshold determined as 0.398. The sensitivity and specificity were calculated as 0.816 and 0.900, respectively, indicating a robust predictive capacity.
UNASSIGNED: This study highlights the significant inverse correlation observed between BMD measured by QCT and both Cobb angle and vertebral rotation angle in patients with AIS. Furthermore, a notable variation in BMD was found across different Risser sign categories, with BMD values generally increasing as Risser sign levels increased. Additionally, our findings indicate that Cobb angle serves as a risk factor for low BMD presence. Moreover, a combined model was developed to predict the likelihood of low BMD occurrence in AIS patients.
UNASSIGNED: A cross-sectional study was conducted on 129 adolescents with AIS who were enrolled at The Third People\'s Hospital of Chengdu, Sichuan, China, between 2021 and 2023. QCT was employed to assess BMD and vertebral rotation. The Cobb angle and Risser sign were determined through radiographic evaluation, while anthropometric and biochemical data were also collected. Statistical analyses, including Pearson and Spearman rank correlation and regression models, were used to investigate the associations between BMD and clinical measures.
UNASSIGNED: A significant negative correlation was found between BMD and Cobb angle (coefficient =-0.663; P<0.001), as well as between BMD and vertebral rotation angle (coefficient =-0.442; P<0.001) in patients with AIS. BMD was positively correlated with increased height (coefficient =0.355; P<0.001) and BMI (coefficient =0.199; P=0.02). A significant association was detected between BMD and the Risser sign (P=0.002). No significant sex-based differences in BMD were observed (P=0.052). No significant correlations were observed between BMD and levels of potassium (K), calcium (Ca), inorganic phosphate (P), and iron (Fe) (P>0.05 all). The binary logistic regression analysis identified Cobb angle as a risk factor of lower BMD presence in AIS patients (coefficient =0.072; OR=1.075; P<0.001). Furthermore, the receiver operating characteristic (ROC) analysis of the combined model for predicting low BMD in AIS patients yielded an area under the curve (AUC) value of 0.900, with an optimal threshold determined as 0.398. The sensitivity and specificity were calculated as 0.816 and 0.900, respectively, indicating a robust predictive capacity.
UNASSIGNED: This study highlights the significant inverse correlation observed between BMD measured by QCT and both Cobb angle and vertebral rotation angle in patients with AIS. Furthermore, a notable variation in BMD was found across different Risser sign categories, with BMD values generally increasing as Risser sign levels increased. Additionally, our findings indicate that Cobb angle serves as a risk factor for low BMD presence. Moreover, a combined model was developed to predict the likelihood of low BMD occurrence in AIS patients.
摘要：
■青少年特发性脊柱侧凸（AIS）是一种普遍存在的脊柱疾病，可能会影响骨密度（BMD）。从而增加骨质疏松症和骨折的易感性。AIS患者骨量减少的早期识别对于临床医生制定有效的骨折预防策略至关重要。本研究旨在阐明BMD之间的相关性，通过定量计算机断层扫描(QCT)测量，以及AIS中的各种临床参数，包括Cobb角,椎骨旋转,和Risser标志。通过揭示这些因素对BMD的潜在影响,我们的发现旨在帮助临床医生做出关于AIS管理的明智和及时的决定，特别是在QCT不可用的情况下。
■对在成都市第三人民医院登记的129名AIS青少年进行了横断面研究，四川,中国,2021年至2023年。QCT用于评估BMD和椎骨旋转。通过射线照相评估确定Cobb角和Risser符号，同时还收集了人体测量和生化数据。统计分析，包括Pearson和Spearman等级相关和回归模型，用于研究BMD与临床测量之间的关联。
■发现BMD与Cobb角之间存在显着负相关（系数=-0.663；P<0.001），以及AIS患者的BMD与椎体旋转角度之间（系数=-0.442；P<0.001）。骨密度与身高增加（系数=0.355；P<0.001）和BMI（系数=0.199；P=0.02）呈正相关。在BMD和Risser符号之间检测到显着关联（P=0.002）。没有观察到BMD的显着性别差异（P=0.052）。BMD和钾（K）水平之间没有观察到显着的相关性，钙(Ca),无机磷酸盐(P),铁(Fe)(均P>0.05)。二元logistic回归分析确定Cobb角是AIS患者BMD降低的危险因素（系数=0.072；OR=1.075；P<0.001）。此外，预测AIS患者低BMD的组合模型的受试者工作特征(ROC)分析得出曲线下面积(AUC)值为0.900,最佳阈值为0.398.敏感性和特异性分别计算为0.816和0.900，表明了强大的预测能力。
■这项研究强调了在AIS患者中通过QCT测量的BMD与Cobb角和椎体旋转角之间观察到的显着负相关。此外，在不同的Risser符号类别中发现了BMD的显着变化，BMD值通常随着Risser符号水平的增加而增加。此外,我们的研究结果表明,Cobb角是低BMD存在的危险因素.此外，我们建立了一个组合模型来预测AIS患者低BMD发生率的可能性.
■对在成都市第三人民医院登记的129名AIS青少年进行了横断面研究，四川,中国,2021年至2023年。QCT用于评估BMD和椎骨旋转。通过射线照相评估确定Cobb角和Risser符号，同时还收集了人体测量和生化数据。统计分析，包括Pearson和Spearman等级相关和回归模型，用于研究BMD与临床测量之间的关联。
■发现BMD与Cobb角之间存在显着负相关（系数=-0.663；P<0.001），以及AIS患者的BMD与椎体旋转角度之间（系数=-0.442；P<0.001）。骨密度与身高增加（系数=0.355；P<0.001）和BMI（系数=0.199；P=0.02）呈正相关。在BMD和Risser符号之间检测到显着关联（P=0.002）。没有观察到BMD的显着性别差异（P=0.052）。BMD和钾（K）水平之间没有观察到显着的相关性，钙(Ca),无机磷酸盐(P),铁(Fe)(均P>0.05)。二元logistic回归分析确定Cobb角是AIS患者BMD降低的危险因素（系数=0.072；OR=1.075；P<0.001）。此外，预测AIS患者低BMD的组合模型的受试者工作特征(ROC)分析得出曲线下面积(AUC)值为0.900,最佳阈值为0.398.敏感性和特异性分别计算为0.816和0.900，表明了强大的预测能力。
■这项研究强调了在AIS患者中通过QCT测量的BMD与Cobb角和椎体旋转角之间观察到的显着负相关。此外，在不同的Risser符号类别中发现了BMD的显着变化，BMD值通常随着Risser符号水平的增加而增加。此外,我们的研究结果表明,Cobb角是低BMD存在的危险因素.此外，我们建立了一个组合模型来预测AIS患者低BMD发生率的可能性.
