PDF(Pubmed)
Abstract：
Having increased popularity during the Covid-19 pandemic, vitamin D3 is currently impressing thanks to the numerous researches aimed at its interactions with the body\'s homeostasis. At the same time, there is a peak in terms of recommendations for supplementation with it. Some of the studies focus on the link between autoimmune diseases and nutritional deficiencies, especially vitamin D3. Since the specialized literature aimed at children (patients between 0-18 years old) is far from equal to the informational diversity of the adult-centered branch, this review aims to bring up to date the relationship between the microbial and nutritional balance and the activity of pediatric systemic lupus erythematosus (pSLE). The desired practical purpose resides in a better understanding and an adequate, individualized management of the affected persons to reduce morbidity. The center of the summary is to establish the impact of hypovitaminosis D in the development and evolution of pediatric lupus erythematosus. We will address aspects related to the two entities of the impact played by vitamin D3 in the pathophysiological cascade of lupus, but also the risk of toxicity and its effects when the deficiency is over supplemented (hypervitaminosis D). We will debate the relationship of hypovitaminosis D with the modulation of immune function, the potentiation of inflammatory processes, the increase of oxidative stress, the perfusion of cognitive brain areas, the seasonal incidence of SLE and its severity. Finally, we review current knowledge, post-pandemic, regarding the hypovitaminosis D - pSLE relationship.
摘要：
在新冠肺炎大流行期间人气上升，维生素D3目前令人印象深刻，这要归功于众多针对其与人体稳态相互作用的研究。同时,在补充建议方面有一个高峰。一些研究集中在自身免疫性疾病和营养缺乏之间的联系，尤其是维生素D3。由于针对儿童（0-18岁之间的患者）的专门文献远远不等于以成人为中心的分支的信息多样性，这篇综述旨在介绍微生物和营养平衡与儿童系统性红斑狼疮（pSLE）活动之间的关系。理想的实际目的在于更好地理解和充分，受影响者的个性化管理，以降低发病率。摘要的中心是建立维生素D缺乏症在小儿红斑狼疮的发展和演变中的影响。我们将讨论与维生素D3在狼疮的病理生理级联中所起的影响的两个实体相关的方面，而且当缺乏过度补充（维生素D过多症）时，毒性的风险及其影响也是如此。我们将讨论维生素D缺乏症与免疫功能调节的关系，炎症过程的增强，氧化应激的增加，认知大脑区域的灌注，SLE的季节性发病率及其严重程度。最后,我们回顾当前的知识，大流行后，关于维生素缺乏症D-pSLE的关系。
