PDF(Pubmed)
Abstract：
UNASSIGNED: The course of coronavirus disease 2019 (COVID-19) is associated with the progression of a wide range of complications, among which thrombosis and thromboembolism are of particular importance. The significance of hypoalbuminemia in the development of thromboembolic complications (TECs) in patients with a severe course of COVID-19 is currently under active discussion. The objective of our study was to evaluate the significance of hypoalbuminemia in the development of TECs in patients with severe SARS-CoV-2 coronavirus infection.
UNASSIGNED: In a single-center observational retrospective study, case histories of 1,634 patients with a verified diagnosis of SARS-CoV-2 coronavirus infection were analyzed. Patients were divided into two groups according to the presence of TECs: 127 patients with venous TECs constituted the main group and 1,507 patients, in whom the course of COVID-19 was not complicated by the development of TECs, constituted the comparison group.
UNASSIGNED: The patients with TECs were older, and the prevalence of arterial hypertension, coronary heart disease, chronic heart failure, chronic kidney disease, and diabetes mellitus was higher than that in the comparison group. A single-factor regression analysis showed that a decrease in albumin levels of less than 35 g/L is associated with an eightfold increase in the risk of developing TECs in patients with severe SARS-CoV-2 coronavirus infection (area under the curve (AUC): 0.815, odds ratio (OR): 8.5389, 95% confidence interval (CI): 4.5637 - 15.977, P < 0.001). The sensitivity of the method was 76.34%, and the specificity was 72.58%.
UNASSIGNED: The study revealed that hypoalbuminemia is a predictor of development of TECs in severe cases of SARS-CoV-2 coronavirus infection.
UNASSIGNED: In a single-center observational retrospective study, case histories of 1,634 patients with a verified diagnosis of SARS-CoV-2 coronavirus infection were analyzed. Patients were divided into two groups according to the presence of TECs: 127 patients with venous TECs constituted the main group and 1,507 patients, in whom the course of COVID-19 was not complicated by the development of TECs, constituted the comparison group.
UNASSIGNED: The patients with TECs were older, and the prevalence of arterial hypertension, coronary heart disease, chronic heart failure, chronic kidney disease, and diabetes mellitus was higher than that in the comparison group. A single-factor regression analysis showed that a decrease in albumin levels of less than 35 g/L is associated with an eightfold increase in the risk of developing TECs in patients with severe SARS-CoV-2 coronavirus infection (area under the curve (AUC): 0.815, odds ratio (OR): 8.5389, 95% confidence interval (CI): 4.5637 - 15.977, P < 0.001). The sensitivity of the method was 76.34%, and the specificity was 72.58%.
UNASSIGNED: The study revealed that hypoalbuminemia is a predictor of development of TECs in severe cases of SARS-CoV-2 coronavirus infection.
摘要：
■2019年冠状病毒病（COVID-19）的病程与各种并发症的进展有关，其中血栓形成和血栓栓塞特别重要。目前正在积极讨论低白蛋白血症在患有严重COVID-19病程的患者血栓栓塞并发症（TECs）发展中的意义。我们研究的目的是评估低蛋白血症在严重SARS-CoV-2冠状病毒感染患者TECs发展中的意义。
■在一项单中心观察性回顾性研究中，分析了1,634例确诊为SARS-CoV-2冠状病毒感染的患者的病史.根据TECs的存在将患者分为两组：127例静脉TECs患者构成主要组，1,507例患者，其中COVID-19的过程并没有因为TECs的发展而变得复杂，构成了比较组。
■患有TECs的患者年龄较大，和动脉高血压的患病率，冠心病,慢性心力衰竭,慢性肾病,糖尿病患者高于对比组。单因素回归分析显示，白蛋白水平降低低于35g/L与严重SARS-CoV-2冠状病毒感染患者发生TECs的风险增加8倍相关（曲线下面积（AUC）：0.815，比值比（OR）：8.5389，95%置信区间（CI）：4.5637～15.977，P<0.001）。方法的灵敏度为76.34%,特异性为72.58%。
■该研究表明，在SARS-CoV-2冠状病毒感染的严重病例中，低白蛋白血症是TECs发展的预测因子。
■在一项单中心观察性回顾性研究中，分析了1,634例确诊为SARS-CoV-2冠状病毒感染的患者的病史.根据TECs的存在将患者分为两组：127例静脉TECs患者构成主要组，1,507例患者，其中COVID-19的过程并没有因为TECs的发展而变得复杂，构成了比较组。
■患有TECs的患者年龄较大，和动脉高血压的患病率，冠心病,慢性心力衰竭,慢性肾病,糖尿病患者高于对比组。单因素回归分析显示，白蛋白水平降低低于35g/L与严重SARS-CoV-2冠状病毒感染患者发生TECs的风险增加8倍相关（曲线下面积（AUC）：0.815，比值比（OR）：8.5389，95%置信区间（CI）：4.5637～15.977，P<0.001）。方法的灵敏度为76.34%,特异性为72.58%。
■该研究表明，在SARS-CoV-2冠状病毒感染的严重病例中，低白蛋白血症是TECs发展的预测因子。
