Abstract：
Background: In order to reduce the risk of leakage of cytotoxic agents, peripherally inserted central catheters (PICC) are widely used in patients diagnosed with malignancy before chemotherapy. While inflammation has been demonstrated to be associated with deep vein thrombosis (DVT), the connection between systemic immune inflammation indexes and the formation of PICC-DVT remains unclear. Purpose: This study aims to evaluate the association between PICC-DVT and systemic immune inflammation indexes including platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI). Methods: From August 2018 to October 2021, we enrolled consecutive patients diagnosed with malignancy who underwent PICC implantation before chemotherapy. DVT was assessed using color Doppler ultrasonography. Results: Among the 513 patients, 57 patients (11.1%) developed PICC-DVT. The optimal cutoff values for PLR, SII and SIRI were 260.1, 1318.7, and 2.7, respectively. Based on the multiple logistic regression analysis, correlations were found between PICC-DVT and elevated PLR (p = .014), SII (p = .012), and SIRI (p = .022). Patients with malignancy having higher values of PLR, SII or SIRI tended to be more likely to develop PICC-DVT. Conclusions: The systemic immune inflammation indexes increases the risk of PICC-DVT and could be used as auxiliary predictive tests for PICC-DVT.
摘要：
背景：为了降低细胞毒性剂泄漏的风险，外周置入中心静脉导管(PICC)广泛应用于化疗前诊断为恶性肿瘤的患者。虽然炎症已被证明与深静脉血栓形成（DVT）有关，全身免疫炎症指标与PICC-DVT形成之间的联系尚不清楚.目的：本研究旨在评估PICC-DVT与包括血小板与淋巴细胞比值（PLR）在内的全身免疫炎症指标之间的关系。全身免疫炎症指数（SII），全身炎症反应指数（SIRI）。方法：2018年8月至2021年10月，我们连续纳入化疗前行PICC植入的恶性肿瘤患者。使用彩色多普勒超声评估DVT。结果:513例患者中,57例（11.1%）患者发生PICC-DVT。PLR的最佳截止值，SII和SIRI分别为260.1、1318.7和2.7。基于多元Logistic回归分析，发现PICC-DVT与PLR升高之间存在相关性(p=0.014)，SII（p=.012），和SIRI（p=.022）。恶性肿瘤患者PLR值较高，SII或SIRI倾向于更有可能发展为PICC-DVT。结论:全身免疫炎症指标增加了PICC-DVT的发生风险,可作为PICC-DVT的辅助预测指标。
