Abstract：
OBJECTIVE: Bladder cancer (BC) is the most common malignant tumour of the urinary system, and radical cystectomy combined with pelvic lymph node dissection (LND) is the standard treatment for BC. We conducted this meta-analysis to explore the efficacy and safety of extended lymph node dissection in radical cystectomy for BC.
METHODS: PubMed, Embase, ProQuest PsycINFO, CINAHL, Web of Science and The Cochrane Library databases were searched for studies on extended lymph node dissection during radical BC surgery. The search time limit was from the establishment of the database to December 2023. Screening and quality assessment of literature were conducted. This meta-analysis was conducted to evaluate the influence of different lymph node dissection methods on recurrence-free survival (RFS), overall survival (OS), operation time, 90-day readmission rate and postoperative complication rate.
RESULTS: A total of 15 studies were included, including 4854 patients. All studies were of high quality. This meta-analysis showed no statistically significant difference in the operation time, postoperative complications and 90-day hospitalisation rate between the two groups of patients. The harvested volume of lymph nodes, RFS and OS rate were not statistically different.
CONCLUSIONS: Among patients with BC undergoing radical cystectomy, extended lymph node dissection did not have a significant effect on operative time, 90-day readmission rates or postoperative complication rates. Thus, extended lymph node dissection is a safe treatment that does not increase the patient\'s surgical risk.
METHODS: PubMed, Embase, ProQuest PsycINFO, CINAHL, Web of Science and The Cochrane Library databases were searched for studies on extended lymph node dissection during radical BC surgery. The search time limit was from the establishment of the database to December 2023. Screening and quality assessment of literature were conducted. This meta-analysis was conducted to evaluate the influence of different lymph node dissection methods on recurrence-free survival (RFS), overall survival (OS), operation time, 90-day readmission rate and postoperative complication rate.
RESULTS: A total of 15 studies were included, including 4854 patients. All studies were of high quality. This meta-analysis showed no statistically significant difference in the operation time, postoperative complications and 90-day hospitalisation rate between the two groups of patients. The harvested volume of lymph nodes, RFS and OS rate were not statistically different.
CONCLUSIONS: Among patients with BC undergoing radical cystectomy, extended lymph node dissection did not have a significant effect on operative time, 90-day readmission rates or postoperative complication rates. Thus, extended lymph node dissection is a safe treatment that does not increase the patient\'s surgical risk.
摘要：
目的：膀胱癌（BC）是泌尿系统最常见的恶性肿瘤，根治性膀胱切除术联合盆腔淋巴结清扫术（LND）是BC的标准治疗方法。我们进行了这项荟萃分析，以探讨在根治性膀胱切除术中扩大淋巴结清扫术的有效性和安全性。
方法：PubMed，Embase,ProQuestPsycINFO,CINAHL,搜索了WebofScience和CochraneLibrary数据库，以进行根治性BC手术期间扩大淋巴结清扫的研究。搜索时间限制是从数据库建立到2023年12月。对文献进行筛选和质量评价。这项荟萃分析旨在评估不同淋巴结清扫方法对无复发生存率（RFS）的影响。总生存期（OS），操作时间,90天再入院率及术后并发症发生率。
结果：共纳入15项研究，包括4854名患者。所有研究都是高质量的。这项荟萃分析显示手术时间无统计学差异，两组患者的术后并发症和90天住院率.收集的淋巴结体积，RFS和OS率无统计学差别。
结论：在接受根治性膀胱切除术的BC患者中，扩大淋巴结清扫术对手术时间没有显著影响,90天再入院率或术后并发症发生率。因此，扩大淋巴结清扫术是一种安全的治疗方法，不会增加患者的手术风险。
方法：PubMed，Embase,ProQuestPsycINFO,CINAHL,搜索了WebofScience和CochraneLibrary数据库，以进行根治性BC手术期间扩大淋巴结清扫的研究。搜索时间限制是从数据库建立到2023年12月。对文献进行筛选和质量评价。这项荟萃分析旨在评估不同淋巴结清扫方法对无复发生存率（RFS）的影响。总生存期（OS），操作时间,90天再入院率及术后并发症发生率。
结果：共纳入15项研究，包括4854名患者。所有研究都是高质量的。这项荟萃分析显示手术时间无统计学差异，两组患者的术后并发症和90天住院率.收集的淋巴结体积，RFS和OS率无统计学差别。
结论：在接受根治性膀胱切除术的BC患者中，扩大淋巴结清扫术对手术时间没有显著影响,90天再入院率或术后并发症发生率。因此，扩大淋巴结清扫术是一种安全的治疗方法，不会增加患者的手术风险。
