METHODS: A retrospective study design was used. The clinical data of 520 patients who underwent rectal prostate biopsy in our hospital from January 2020 to June 2023 were analysed. The patients were enrolled and divided into the anterior PCa group including 112 patients and benign prostatic hyperplasia (BPH) group including 408 patients. Univariate and multivariate logistic regression analyses were performed for the two patient groups, and further comparisons were made according to the Gleason score and TNM staging.
RESULTS: Low-density lipoprotein cholesterol (LDL-C) level may be an independent risk factor for PCa, and it was significantly associated with the risk of PCa (odds ratio (OR) = 1.363, p = 0.030). Patients with PCa were further divided into the low risk group and the high risk group according to the Gleason score. Univariate analysis (p = 0.047) and logistic regression analysis (OR = 2.249, p = 0.036) revealed that LDL-C was a significant factor influencing the Gleason score. Patients with PCa were categorised into four groups based on TNM staging. One-way analysis of variance (ANOVA) analysis (p = 0.015) and ordinal logistic regression analysis (OR = 2.414, p = 0.007) demonstrated that LDL-C was a significant factor influencing TNM staging.
CONCLUSIONS: This study revealed the important role of LDL-C in the development of PCa, highlighting its influence as an independent risk factor. Thus, LDL-C may promote the proliferation and invasion of PCa cells.
方法:采用回顾性研究设计。回顾性分析2020年1月至2023年6月在我院行直肠前列腺穿刺活检的520例患者的临床资料。将患者分为前PCa组(112例)和良性前列腺增生(BPH)组(408例)。对两组患者进行了单变量和多变量逻辑回归分析,并根据Gleason评分和TNM分期进行进一步比较。
结果:低密度脂蛋白胆固醇(LDL-C)水平可能是PCa的独立危险因素,并且与PCa的风险显著相关(比值比(OR)=1.363,p=0.030)。根据Gleason评分将PCa患者进一步分为低风险组和高风险组。单因素分析(p=0.047)和逻辑回归分析(OR=2.249,p=0.036)显示LDL-C是影响Gleason评分的重要因素。根据TNM分期将PCa患者分为四组。单因素方差分析(ANOVA)分析(p=0.015)和有序logistic回归分析(OR=2.414,p=0.007)表明LDL-C是影响TNM分期的重要因素。
结论:这项研究揭示了LDL-C在PCa发展中的重要作用,强调其作为独立风险因素的影响。因此,LDL-C可以促进PCa细胞的增殖和侵袭。