PDF(Pubmed)
Abstract：
BACKGROUND: Aging has been associated with a progressive loss of skeletal muscle quality, quantity and strength, which may result in a condition known as sarcopenia, leading to a decline in physical performance, loss of independence and reduced quality of life. While the cause of impaired physical functioning observed in elderly populations appears to be multifactorial, recent evidence suggests that age-associated alterations in gut microbiota could be a contributing factor. The primary objective will be to assess the effects of a dietary synbiotic formulation on sarcopenia-related functional outcomes such as handgrip strength, gait speed and physical performance within older individuals living independently. The secondary objective will be to examine associations between changes in gut microbiota composition, functional performance and lean muscle mass.
METHODS: Seventy-four elderly (60-85 years) participants will be randomized in a double-blind, placebo-controlled fashion to either an intervention or control group. The intervention group (n = 37) will receive oral synbiotic formulation daily for 16 weeks. The control group (n = 37) will receive placebo. Assessments of physical performance (including Short Physical Performance Battery, handgrip strength and timed up-and-go tests) and muscle ultrasonography will be performed at 4 time points (baseline and weeks 8, 16 and 20). Likewise, body composition via bioelectric impedance analysis and blood and stool samples will be collected at each time point. Dual-energy X-ray absorptiometry will be performed at baseline and week 16. The primary outcomes will be between-group changes in physical performance from baseline to 16 weeks. Secondary outcomes include changes in body composition, muscle mass and architecture, fecal microbiota composition and diversity, and fecal and plasma metabolomics.
CONCLUSIONS: Gut-modulating supplements appear to be effective in modifying gut microbiota composition in healthy older adults. However, it is unclear whether these changes translate into functional and/or health improvements. In the present study, we will investigate the effects of a synbiotic formulation on measures of physical performance, strength and muscle health in healthy older populations.
BACKGROUND: This study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000652774) in May 2022.
METHODS: Seventy-four elderly (60-85 years) participants will be randomized in a double-blind, placebo-controlled fashion to either an intervention or control group. The intervention group (n = 37) will receive oral synbiotic formulation daily for 16 weeks. The control group (n = 37) will receive placebo. Assessments of physical performance (including Short Physical Performance Battery, handgrip strength and timed up-and-go tests) and muscle ultrasonography will be performed at 4 time points (baseline and weeks 8, 16 and 20). Likewise, body composition via bioelectric impedance analysis and blood and stool samples will be collected at each time point. Dual-energy X-ray absorptiometry will be performed at baseline and week 16. The primary outcomes will be between-group changes in physical performance from baseline to 16 weeks. Secondary outcomes include changes in body composition, muscle mass and architecture, fecal microbiota composition and diversity, and fecal and plasma metabolomics.
CONCLUSIONS: Gut-modulating supplements appear to be effective in modifying gut microbiota composition in healthy older adults. However, it is unclear whether these changes translate into functional and/or health improvements. In the present study, we will investigate the effects of a synbiotic formulation on measures of physical performance, strength and muscle health in healthy older populations.
BACKGROUND: This study was prospectively registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000652774) in May 2022.
摘要：
背景：衰老与骨骼肌质量的进行性下降有关，数量和强度，这可能会导致一种称为肌肉减少症的疾病，导致身体性能下降，失去独立性和降低生活质量。虽然在老年人群中观察到的身体功能受损的原因似乎是多因素的，最近的证据表明,与年龄相关的肠道菌群改变可能是一个促成因素.主要目标是评估饮食合生元配方对肌肉减少症相关功能结果的影响，如握力，独立生活的老年人的步态速度和身体表现。次要目标是检查肠道微生物群组成变化之间的关联，功能表现和瘦肌肉质量。
方法：74名老年（60-85岁）参与者将被随机双盲，对干预组或对照组进行安慰剂对照。干预组(n=37)将每天接受口服合生元制剂,持续16周。对照组(n=37)将接受安慰剂。物理性能评估（包括短物理性能电池，将在4个时间点（基线和第8周，第16周和第20周）进行手握力量和定时上行测试）和肌肉超声检查。同样，通过生物电阻抗分析和血液和粪便样本将在每个时间点收集身体成分。将在基线和第16周进行双能X射线吸收测定。主要结果将是从基线到16周的身体表现的组间变化。次要结果包括身体成分的变化，肌肉质量和结构，粪便微生物群组成和多样性，粪便和血浆代谢组学。
结论：肠道调节补充剂似乎可有效改变健康老年人的肠道菌群组成。然而,目前尚不清楚这些变化是否转化为功能和/或健康改善.在本研究中,我们将研究合生元配方对身体性能测量的影响，健康老年人群的力量和肌肉健康。
背景：这项研究于2022年5月在澳大利亚新西兰临床试验注册中心（ACTRN12622000652774）进行了前瞻性注册。
方法：74名老年（60-85岁）参与者将被随机双盲，对干预组或对照组进行安慰剂对照。干预组(n=37)将每天接受口服合生元制剂,持续16周。对照组(n=37)将接受安慰剂。物理性能评估（包括短物理性能电池，将在4个时间点（基线和第8周，第16周和第20周）进行手握力量和定时上行测试）和肌肉超声检查。同样，通过生物电阻抗分析和血液和粪便样本将在每个时间点收集身体成分。将在基线和第16周进行双能X射线吸收测定。主要结果将是从基线到16周的身体表现的组间变化。次要结果包括身体成分的变化，肌肉质量和结构，粪便微生物群组成和多样性，粪便和血浆代谢组学。
结论：肠道调节补充剂似乎可有效改变健康老年人的肠道菌群组成。然而,目前尚不清楚这些变化是否转化为功能和/或健康改善.在本研究中,我们将研究合生元配方对身体性能测量的影响，健康老年人群的力量和肌肉健康。
背景：这项研究于2022年5月在澳大利亚新西兰临床试验注册中心（ACTRN12622000652774）进行了前瞻性注册。
