Abstract：
OBJECTIVE: Walking pace is associated with risks of major chronic diseases including cancer, cardiovascular disease (CVD) and diabetes mellitus type 2 (T2DM) in the general population. However, whether increasing walking pace could reduce risks of major chronic diseases in individuals with hypertension remains to be explored, and the underlying mechanism potentially mediated by low-grade inflammation is also unclear.
METHODS: A total of 160,470 participants with hypertension were included based on the UK Biobank. The relationships of the walking pace and low-grade inflammation with risks of major chronic diseases in individuals with hypertension were assessed by the Cox proportional hazards model. Mediation analyses were performed to investigate the contribution of low-grade inflammation to the association between walking pace and risks of major chronic diseases.
RESULTS: Individuals with hypertension at the brisk walking pace had decreased risks of overall cancer and site-specific cancers (liver, lung, and endometrial cancers), all CVD events (angina, atrial fibrillation, heart failure, myocardial infarction, peripheral vascular disease and stroke), and T2DM (hazard ratios: 0.42-0.91). Increasing low-grade inflammation was associated with higher risks of aforementioned diseases except liver cancer and atrial fibrillation. Furthermore, low-grade inflammation partially mediated associations of the walking pace with risks of lung cancer, T2DM, and all CVD events (except atrial fibrillation), with mediation proportion of 2.0%-9.8%.
CONCLUSIONS: Brisk walking pace was linked to reduced risks of major chronic diseases in individuals with hypertension, partially mediated by low-grade inflammation. Improving walking pace may be beneficial for health in individuals with hypertension.
METHODS: A total of 160,470 participants with hypertension were included based on the UK Biobank. The relationships of the walking pace and low-grade inflammation with risks of major chronic diseases in individuals with hypertension were assessed by the Cox proportional hazards model. Mediation analyses were performed to investigate the contribution of low-grade inflammation to the association between walking pace and risks of major chronic diseases.
RESULTS: Individuals with hypertension at the brisk walking pace had decreased risks of overall cancer and site-specific cancers (liver, lung, and endometrial cancers), all CVD events (angina, atrial fibrillation, heart failure, myocardial infarction, peripheral vascular disease and stroke), and T2DM (hazard ratios: 0.42-0.91). Increasing low-grade inflammation was associated with higher risks of aforementioned diseases except liver cancer and atrial fibrillation. Furthermore, low-grade inflammation partially mediated associations of the walking pace with risks of lung cancer, T2DM, and all CVD events (except atrial fibrillation), with mediation proportion of 2.0%-9.8%.
CONCLUSIONS: Brisk walking pace was linked to reduced risks of major chronic diseases in individuals with hypertension, partially mediated by low-grade inflammation. Improving walking pace may be beneficial for health in individuals with hypertension.
摘要：
目标：步行速度与包括癌症在内的主要慢性疾病的风险有关。一般人群中的心血管疾病（CVD）和2型糖尿病（T2DM）。然而,增加步行速度是否可以降低高血压患者患主要慢性疾病的风险还有待探索。低度炎症可能介导的潜在机制也不清楚.
方法：根据UKBiobank纳入了160,470名高血压患者。通过Cox比例风险模型评估了高血压患者步行速度和低度炎症与主要慢性疾病风险的关系。进行中介分析以研究低度炎症对步行速度与主要慢性疾病风险之间的关联的贡献。
结果：快步走的高血压患者患整体癌症和特定部位癌症的风险降低（肝癌，肺，和子宫内膜癌），所有CVD事件（心绞痛，心房颤动,心力衰竭,心肌梗塞,外周血管疾病和中风)，和T2DM（危险比：0.42-0.91）。除肝癌和心房颤动外，低度炎症的增加与上述疾病的高风险相关。此外，低度炎症部分介导步行速度与肺癌风险的关联，T2DM,和所有心血管事件（房颤除外），调解比例为2.0%-9.8%。
结论：快步走与高血压患者重大慢性疾病风险降低有关，部分由低度炎症介导。改善步行速度可能对高血压患者的健康有益。
方法：根据UKBiobank纳入了160,470名高血压患者。通过Cox比例风险模型评估了高血压患者步行速度和低度炎症与主要慢性疾病风险的关系。进行中介分析以研究低度炎症对步行速度与主要慢性疾病风险之间的关联的贡献。
结果：快步走的高血压患者患整体癌症和特定部位癌症的风险降低（肝癌，肺，和子宫内膜癌），所有CVD事件（心绞痛，心房颤动,心力衰竭,心肌梗塞,外周血管疾病和中风)，和T2DM（危险比：0.42-0.91）。除肝癌和心房颤动外，低度炎症的增加与上述疾病的高风险相关。此外，低度炎症部分介导步行速度与肺癌风险的关联，T2DM,和所有心血管事件（房颤除外），调解比例为2.0%-9.8%。
结论：快步走与高血压患者重大慢性疾病风险降低有关，部分由低度炎症介导。改善步行速度可能对高血压患者的健康有益。
