PDF(Pubmed)
Abstract：
Tight junctions (TJs) are specialized regions of contact between cells of epithelial and endothelial tissues that form selective semipermeable paracellular barriers that establish and maintain body compartments with different fluid compositions. As such, the formation of TJs represents a critical step in metazoan evolution, allowing the formation of multicompartmental organisms and true, barrier-forming epithelia and endothelia. In the six decades that have passed since the first observations of TJs by transmission electron microscopy, much progress has been made in understanding the structure, function, molecular composition and regulation of TJs. The goal of this Perspective is to highlight the key concepts that have emerged through this research and the future challenges that lie ahead for the field.
摘要：
紧密连接(TJ)是上皮和内皮组织细胞之间的专门接触区域,其形成选择性半透性细胞旁屏障,其建立和维持具有不同流体组成的身体区室。因此，TJ的形成代表了后生动物进化的关键步骤，允许形成多隔室生物，形成屏障的上皮和内皮。自透射电子显微镜首次观察TJ以来的六十年中，在理解结构方面取得了很大进展，函数,TJs的分子组成和调控。这个观点的目标是强调通过这项研究出现的关键概念以及该领域未来的挑战。
