PDF(Pubmed)
Abstract：
The fallopian tubes play an important role in human fertility by facilitating the spermatozoa passage to the oocyte as well as later actively facilitating the fertilized oocyte transportation to the uterus cavity. The fallopian tubes undergo changes involving biological, physical, and morphological processes due to women aging, which may impair fertility. Here, we have modelled fallopian tubes of women at different ages and evaluated the chances of normal and pathological sperm cells reaching the fertilization site, the ampulla. By utilizing a unique combination of simulative tools, we implemented dynamic three-dimensional (3D) detailed geometrical models of many normal and pathological sperm cells swimming together in 3D geometrical models of three fallopian tubes associated with different women\'s age groups. By tracking the sperm cell swim, we found that for all age groups, the number of normal sperm cells in the ampulla is the largest, compared with the pathological sperm cells. On the other hand, the number of normal sperm cells in the fertilization site decreases due to the morphological and mechanical changes that occur in the fallopian tube with age. Moreover, in older ages, the normal sperm cells swim with lower velocities and for shorter distances inside the ampulla toward the ovary. Thus, the changes that the human fallopian tube undergoes due to women\'s aging have a significant influence on the human sperm cell motility. Our model of sperm cell motility through the fallopian tube in relation to the woman\'s age morphological changes provides a new scope for the investigation and treatment of diseases and infertility cases associated with aging, as well as a potential personalized medicine tool for evaluating the chances of a natural fertilization per specific features of a man\'s sperm and a woman\'s reproductive system.
摘要：
输卵管通过促进精子进入卵母细胞以及随后积极促进受精的卵母细胞运输到子宫腔,在人类生育中起重要作用。输卵管经历了涉及生物的变化，物理，和女性衰老导致的形态学过程，这可能会损害生育能力。这里,我们模拟了不同年龄女性的输卵管，并评估了正常和病理性精子细胞到达受精部位的机会，安普拉。通过利用模拟工具的独特组合，我们实施了许多正常和病理性精子细胞一起游泳的动态三维（3D）详细几何模型，在与不同年龄段女性相关的三个输卵管的3D几何模型中。通过追踪精子细胞游泳，我们发现，对于所有年龄组，壶腹正常精子细胞数量最多,与病理精子细胞相比。另一方面,由于输卵管随着年龄的增长而发生的形态和机械变化，受精部位的正常精子细胞数量减少。此外，在老年，正常的精子细胞在壶腹内以较低的速度和较短的距离向卵巢游动。因此，由于女性的衰老而引起的人体输卵管的变化对人体精子细胞的运动具有重要的影响。我们的精子细胞运动通过输卵管与女性年龄形态变化的关系模型为研究和治疗与衰老相关的疾病和不孕症病例提供了新的范围。也是一个潜在的个性化医疗工具，用于评估男性精子和女性生殖系统的特定特征自然受精的机会。
