PDF(Pubmed)
Abstract：
UNASSIGNED: Multicentric reticulohistiocytosis (MRH) stands as a rare and challenging systemic granulomatous disease characterized by its predilection for skin and joint involvement, confounding clinicians with its infrequent presentation and systemic manifestations.
UNASSIGNED: This compelling case presentation unravels the intricate complexity of MRH, exemplifying its unique clinical course. Following mild upper respiratory coronavirus disease 2019 (COVID-19) symptoms, the patient manifested purplish-pink papular lesions on both the skin and mucosa, accompanied by debilitating arthralgias. A diagnostic skin biopsy, a pivotal tool in MRH diagnosis, confirmed the presence of this granulomatous disorder, underlining its systemic impact. Strategic therapeutic intervention involving a combination of steroids and methotrexate demonstrated remarkable efficacy, culminating in the resolution of symptoms within 3-month. The absence of malignancy upon thorough screening further amplifies the perplexing nature of MRH.
UNASSIGNED: This seminal case not only bridges the realms of rare systemic disorders but also marks the first known instance of MRH emerging post-COVID-19. It underscores the imperative consideration of MRH in analogous scenarios and provides invaluable insights into the nuanced interplay of MRH symptoms, diagnosis, and therapeutic strategies following viral triggers. This comprehensive exploration enriches our scientific understanding, offering nuanced perspectives on the manifestations and intricate dynamics of MRH in the context of post-viral sequelae.
UNASSIGNED: This compelling case presentation unravels the intricate complexity of MRH, exemplifying its unique clinical course. Following mild upper respiratory coronavirus disease 2019 (COVID-19) symptoms, the patient manifested purplish-pink papular lesions on both the skin and mucosa, accompanied by debilitating arthralgias. A diagnostic skin biopsy, a pivotal tool in MRH diagnosis, confirmed the presence of this granulomatous disorder, underlining its systemic impact. Strategic therapeutic intervention involving a combination of steroids and methotrexate demonstrated remarkable efficacy, culminating in the resolution of symptoms within 3-month. The absence of malignancy upon thorough screening further amplifies the perplexing nature of MRH.
UNASSIGNED: This seminal case not only bridges the realms of rare systemic disorders but also marks the first known instance of MRH emerging post-COVID-19. It underscores the imperative consideration of MRH in analogous scenarios and provides invaluable insights into the nuanced interplay of MRH symptoms, diagnosis, and therapeutic strategies following viral triggers. This comprehensive exploration enriches our scientific understanding, offering nuanced perspectives on the manifestations and intricate dynamics of MRH in the context of post-viral sequelae.
摘要：
■多中心网状组织细胞增生症（MRH）是一种罕见且具有挑战性的全身性肉芽肿性疾病，其特征是皮肤和关节受累。混淆临床医生的罕见表现和系统性表现。
■这个令人信服的案例演示揭示了MRH复杂的复杂性，举例说明其独特的临床过程。继2019年轻度上呼吸道冠状病毒病（COVID-19）症状后，患者表现为皮肤和粘膜上的紫粉红色丘疹性病变，伴随着衰弱的关节病。诊断性皮肤活检,MRH诊断的关键工具，证实了这种肉芽肿性疾病的存在，强调其系统性影响。涉及类固醇和甲氨蝶呤组合的战略治疗干预显示出显著的疗效。最终在3个月内症状的解决。彻底筛查后没有恶性肿瘤进一步放大了MRH的困惑性质。
■这一开创性病例不仅弥合了罕见的系统性疾病的领域，而且标志着MRH在COVID-19后出现的第一个已知实例。它强调了在类似情况下对MRH的必要考虑，并为MRH症状的细微差别相互作用提供了宝贵的见解，诊断,以及病毒触发因素后的治疗策略。这种全面的探索丰富了我们的科学认识,在病毒后后遗症的背景下，对MRH的表现和复杂的动态提供细微差别的观点。
■这个令人信服的案例演示揭示了MRH复杂的复杂性，举例说明其独特的临床过程。继2019年轻度上呼吸道冠状病毒病（COVID-19）症状后，患者表现为皮肤和粘膜上的紫粉红色丘疹性病变，伴随着衰弱的关节病。诊断性皮肤活检,MRH诊断的关键工具，证实了这种肉芽肿性疾病的存在，强调其系统性影响。涉及类固醇和甲氨蝶呤组合的战略治疗干预显示出显著的疗效。最终在3个月内症状的解决。彻底筛查后没有恶性肿瘤进一步放大了MRH的困惑性质。
■这一开创性病例不仅弥合了罕见的系统性疾病的领域，而且标志着MRH在COVID-19后出现的第一个已知实例。它强调了在类似情况下对MRH的必要考虑，并为MRH症状的细微差别相互作用提供了宝贵的见解，诊断,以及病毒触发因素后的治疗策略。这种全面的探索丰富了我们的科学认识,在病毒后后遗症的背景下，对MRH的表现和复杂的动态提供细微差别的观点。
