PDF(Pubmed)
Abstract：
UNASSIGNED: Hemoglobin A1c (HbA1c) serves as a pivotal marker for long-term glycemic control. The Diabetes Control and Complications Trial (DCCT) established its relevance, yet gaps exist in understanding potential seasonal variations in HbA1c levels among diabetic patients. The study highlights the need to explore potential seasonal variations in HbA1c levels and their impact on diabetic patients.
UNASSIGNED: This is an observational study conducted in a tertiary care hospital from January to December 2019, the study analyzed HbA1c levels in 8138 patients. Blood samples were collected using Potassium EDTA-containing vials and processed with an automated analyzer. Seasonal variations were explored using time series analysis.
UNASSIGNED: Mean HbA1c levels peaked during the monsoon (June to September) and were lowest in autumn (October to November). Subgroup analysis revealed differences in patients with HbA1c values below and above 6.5 %. Those with controlled blood sugar showed higher levels in winter (December to February) and monsoon (June to September), while patients with HbA1c values ≥ 6.5 % exhibited significantly lower levels in monsoon (June to September) and autumn (October to November) compared to summer (March to May).
UNASSIGNED: In contrast to global trends, Indian patients demonstrated distinct seasonal variations in HbA1c levels. The highest levels during the monsoon (June to September) may be linked to reduced outdoor activity and dietary changes. The study emphasizes the need for tailored diabetes management considering seasonal influences. Further extensive, longitudinal studies across diverse Indian regions are recommended to comprehensively grasp the impact of seasonal changes on diabetes outcomes.
UNASSIGNED: This is an observational study conducted in a tertiary care hospital from January to December 2019, the study analyzed HbA1c levels in 8138 patients. Blood samples were collected using Potassium EDTA-containing vials and processed with an automated analyzer. Seasonal variations were explored using time series analysis.
UNASSIGNED: Mean HbA1c levels peaked during the monsoon (June to September) and were lowest in autumn (October to November). Subgroup analysis revealed differences in patients with HbA1c values below and above 6.5 %. Those with controlled blood sugar showed higher levels in winter (December to February) and monsoon (June to September), while patients with HbA1c values ≥ 6.5 % exhibited significantly lower levels in monsoon (June to September) and autumn (October to November) compared to summer (March to May).
UNASSIGNED: In contrast to global trends, Indian patients demonstrated distinct seasonal variations in HbA1c levels. The highest levels during the monsoon (June to September) may be linked to reduced outdoor activity and dietary changes. The study emphasizes the need for tailored diabetes management considering seasonal influences. Further extensive, longitudinal studies across diverse Indian regions are recommended to comprehensively grasp the impact of seasonal changes on diabetes outcomes.
摘要：
■血红蛋白A1c(HbA1c)是长期血糖控制的关键标志物。糖尿病控制和并发症试验（DCCT）确立了其相关性，然而,在了解糖尿病患者HbA1c水平的潜在季节性变化方面存在差距.该研究强调需要探索HbA1c水平的潜在季节性变化及其对糖尿病患者的影响。
■这是一项观察性研究，于2019年1月至12月在三级护理医院进行，该研究分析了8138名患者的HbA1c水平。使用含EDTA钾的小瓶收集血液样品并用自动分析仪处理。使用时间序列分析探索了季节性变化。
平均HbA1c水平在季风期间（6月至9月）达到峰值，在秋季（10月至11月）达到最低。亚组分析显示HbA1c值低于和高于6.5%的患者存在差异。那些控制血糖的人在冬季（12月至2月）和季风（6月至9月）显示出更高的水平，而HbA1c值≥6.5%的患者在季风(6月至9月)和秋季(10月至11月)的水平明显低于夏季(3月至5月).
■与全球趋势相反，印度患者HbA1c水平表现出明显的季节性变化。季风期间（6月至9月）的最高水平可能与户外活动减少和饮食变化有关。该研究强调需要考虑季节性影响的量身定制的糖尿病管理。进一步广泛,建议在印度不同地区进行纵向研究,以全面掌握季节变化对糖尿病结局的影响.
■这是一项观察性研究，于2019年1月至12月在三级护理医院进行，该研究分析了8138名患者的HbA1c水平。使用含EDTA钾的小瓶收集血液样品并用自动分析仪处理。使用时间序列分析探索了季节性变化。
平均HbA1c水平在季风期间（6月至9月）达到峰值，在秋季（10月至11月）达到最低。亚组分析显示HbA1c值低于和高于6.5%的患者存在差异。那些控制血糖的人在冬季（12月至2月）和季风（6月至9月）显示出更高的水平，而HbA1c值≥6.5%的患者在季风(6月至9月)和秋季(10月至11月)的水平明显低于夏季(3月至5月).
■与全球趋势相反，印度患者HbA1c水平表现出明显的季节性变化。季风期间（6月至9月）的最高水平可能与户外活动减少和饮食变化有关。该研究强调需要考虑季节性影响的量身定制的糖尿病管理。进一步广泛,建议在印度不同地区进行纵向研究,以全面掌握季节变化对糖尿病结局的影响.
