PDF(Pubmed)
Abstract：
Although evidence indicates that the adult brain retains a considerable capacity for circuit formation, adult wiring has not been broadly considered and remains poorly understood. In this study, we investigate wiring activation in adult neurons. We show that the basic-helix-loop-helix transcription factor Ascl4 can induce wiring in different types of hippocampal neurons of adult mice. The new axons are mainly feedforward and reconfigure synaptic weights in the circuit. Mice with the Ascl4-induced circuits do not display signs of pathology and solve spatial problems equally well as controls. Our results demonstrate reprogrammed connectivity by a single transcriptional factor and provide insights into the regulation of brain wiring in adults.
摘要：
尽管有证据表明成人大脑保留了相当大的电路形成能力，成人布线尚未被广泛考虑，仍然知之甚少。在这项研究中,我们研究了成年神经元的导线激活。我们表明，碱性-螺旋-环-螺旋转录因子Ascl4可以诱导成年小鼠不同类型海马神经元的布线。新轴突主要是前馈和重新配置电路中的突触权重。具有Ascl4诱导的回路的小鼠不显示病理迹象，并且与对照组一样解决空间问题。我们的结果证明了通过单个转录因子重新编程的连接性，并提供了对成人大脑布线调节的见解。
