PDF(Pubmed)
Abstract：
Chronic pulmonary aspergillosis is a lung disorder characterized by the presence of single or multiple cavities with or without an aspergilloma or nodules on chest imaging, with mycological evidence of and/or demonstration of immunological response to Aspergillus spp. The affected patient should manifest relevant symptoms for at least 3 months. Chronic cavitary pulmonary aspergillosis is the most common subset of chronic pulmonary aspergillosis, which is often reported in patients previously treated for pulmonary tuberculosis, having residual cavities in their lungs. We present a case of a 55-year-old male patient treated for pulmonary tuberculosis 2 years back, now presenting with fever, shortness of breath, and hemoptysis with overt radiological changes from the baseline, positive direct microscopy, and serology for Aspergillus spp. and thus meeting the criteria for chronic cavitary pulmonary aspergillosis. Treatment with oral antifungal was initiated, but the follow-up data are unavailable due to patient noncompliance and lack of resources. We aim to emphasize the radiological and microbiological features of this condition to aid the early diagnosis and prompt treatment, as this may mimic similar pulmonary disorders and pose a significant challenge in the diagnosis and management outcomes.
摘要：
慢性肺曲霉病是一种肺部疾病，其特征是存在单个或多个腔，在胸部成像上有或没有曲霉菌瘤或结节，具有对曲霉属的免疫反应的真菌学证据和/或证明。受影响的患者应出现相关症状至少3个月。慢性空洞性肺曲霉病是慢性肺曲霉病最常见的亚组,通常在以前接受过肺结核治疗的患者中报告，在他们的肺部有残留的空洞。我们介绍了一名55岁的男性患者，两年前接受肺结核治疗，现在出现发烧，呼吸急促,咯血与基线相比有明显的放射学变化，阳性直接显微镜，和曲霉属的血清学。因此符合慢性空洞性肺曲霉病的标准。开始口服抗真菌药物治疗，但由于患者不合规和缺乏资源,无法获得随访数据.我们的目标是强调这种情况的放射学和微生物学特征，以帮助早期诊断和及时治疗，因为这可能与类似的肺部疾病相似，并且对诊断和治疗结果构成重大挑战。
