关键词: Climate change Dysbiosis Gut microbiome Industrial agriculture Non-communicable chronic disease Plant microbiome Plant-based diet Regenerative agriculture Soil microbiome

来  源:   DOI:10.1016/j.onehlt.2024.100734   PDF(Pubmed)

Abstract:
Non-communicable diseases (NCDs) pose a global health challenge, leading to substantial morbidity, mortality, and economic strain. Our review underscores the escalating incidence of NCDs worldwide and highlights the potential of regenerative agriculture (RA) products in mitigating these diseases. We also explore the efficacy of dietary interventions in NCD management and prevention, emphasizing the superiority of plant-based diets over those high in processed foods and red meat. Examining the role of the gut microbiome in various diseases, including liver disorders, allergies, metabolic syndrome, inflammatory bowel disease, and colon cancer, we find compelling evidence implicating its influence on disease development. Notably, dietary modifications can positively affect the gut microbiome, fostering a symbiotic relationship with the host and making this a critical strategy in disease prevention and treatment. Investigating agricultural practices, we identify parallels between soil/plant and human microbiome studies, suggesting a crucial link between soil health, plant- and animal-derived food quality, and human well-being. Conventional/Industrial agriculture (IA) practices, characterized in part by use of chemical inputs, have adverse effects on soil microbiome diversity, food quality, and ecosystems. In contrast, RA prioritizes soil health through natural processes, and includes avoiding synthetic inputs, crop rotation, and integrating livestock. Emerging evidence suggests that food from RA systems surpasses IA-produced food in quality and nutritional value. Recognizing the interconnection between human, plant, and soil microbiomes, promoting RA-produced foods emerges as a strategy to improve human health and environmental sustainability. By mitigating climate change impacts through carbon sequestration and water cycling, RA offers dual benefits for human and planetary health and well-being. Emphasizing the pivotal role of diet and agricultural practices in combating NCDs and addressing environmental concerns, the adoption of regional RA systems becomes imperative. Increasing RA integration into local food systems can enhance food quality, availability, and affordability while safeguarding human health and the planet\'s future.
摘要:
非传染性疾病构成全球卫生挑战,导致大量的发病率,死亡率,和经济压力。我们的审查强调了全球非传染性疾病发病率的上升,并强调了再生农业(RA)产品在缓解这些疾病方面的潜力。我们还探讨了饮食干预在非传染性疾病管理和预防中的功效,强调植物性饮食优于加工食品和红肉。检查肠道微生物组在各种疾病中的作用,包括肝脏疾病,过敏,代谢综合征,炎症性肠病,结肠癌,我们发现了令人信服的证据表明其对疾病发展的影响。值得注意的是,饮食调整可以积极影响肠道微生物组,促进与宿主的共生关系,并使其成为疾病预防和治疗的关键策略。调查农业实践,我们确定了土壤/植物和人类微生物组研究之间的相似之处,表明土壤健康之间的关键联系,植物和动物源性食品质量,和人类福祉。传统/工业农业(IA)实践,部分特征在于使用化学输入,对土壤微生物多样性有不利影响,食物质量,和生态系统。相比之下,RA通过自然过程优先考虑土壤健康,包括避免合成投入,作物轮作,整合牲畜。新出现的证据表明,来自RA系统的食物在质量和营养价值上超过IA生产的食物。认识到人与人之间的相互联系,植物,和土壤微生物组,促进RA生产的食品成为改善人类健康和环境可持续性的战略。通过碳封存和水循环减轻气候变化的影响,RA为人类和行星的健康和福祉提供双重益处。强调饮食和农业做法在防治非传染性疾病和解决环境问题方面的关键作用,采用区域RA系统变得势在必行。增加RA融入当地食品系统可以提高食品质量,可用性,和负担能力,同时保护人类健康和地球的未来。
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