METHODS: The study included 45 patients who were diagnosed with prostatic carcinoma and underwent radical prostatectomy in our center between the years 2010 and 2021. Pathology reports were reviewed. Mann-Whitney U test was used for the comparison of RRBP1 and GADPH values of the cases (control and tumoral tissue) between the primary tumor stage (pT) and Gleason score (GS) groups. Hierarchical regression analysis was used to explain the effective variables in explaining the RRBP1 value of the research cases.
RESULTS: According to the Mann-Whitney U test, mean and median RRBP1-T values of the cases with GS ≥ 8 were detected to be statistically significantly higher than the mean and median RRBP1-T values of the cases with GS < 8.
CONCLUSIONS: We found out that RRBP1 was expressed at higher rates in patients with high GS and advanced-stage patients. This result indicated that RRBP1 expression may be important in predicting the prognosis of prostate carcinoma.
方法:该研究包括2010年至2021年在我们中心诊断为前列腺癌并接受前列腺癌根治术的45例患者。回顾病理报告。使用Mann-WhitneyU检验比较原发性肿瘤分期(pT)和Gleason评分(GS)组之间病例(对照和肿瘤组织)的RRBP1和GADPH值。采用层次回归分析解释研究案例RRBP1值的有效变量。
结果:根据Mann-WhitneyU检验,GS≥8例的平均和中位RRBP1-T值在统计学上显著高于GS<8例的平均和中位RRBP1-T值.
结论:我们发现RRBP1在高GS患者和晚期患者中的表达率较高。提示RRBP1的表达对预测前列腺癌的预后有重要意义。