关键词: Drug development Malaria Plasmodium falciparum R21/Matrix-M RTS,S/AS01 Vaccines mRNA

Mesh : Humans Disease Eradication / methods Global Health Malaria / immunology prevention & control Malaria Vaccines / immunology genetics Pharmaceutical Research mRNA Vaccines / immunology Africa

来  源:   DOI:10.1186/s12936-024-04972-5   PDF(Pubmed)

Abstract:
Malaria vaccine introduction in endemic countries is a game-changing milestone in the fight against the disease. This article examines the inequity in the global pharmaceutical research, development, manufacturing, and trade landscape. The role of inequity in hindering progress towards malaria elimination is explored. The analysis finds that transformational changes are required to create an equity-enabling environment. Addressing the inequity is critical to maximizing the public health impact of vaccines and attaining sustainability. Avenues to catalyze progress by leveraging malaria vaccines and messenger ribonucleic acid (mRNA) technology are discussed.
摘要:
在流行国家引入疟疾疫苗是抗击该疾病的一个改变游戏规则的里程碑。本文探讨了全球制药研究中的不公平现象,发展,制造,和贸易格局。探讨了不平等在阻碍消除疟疾方面的作用。分析发现,要创造有利于公平的环境,需要进行转型变革。解决不平等问题对于最大限度地提高疫苗对公共卫生的影响和实现可持续性至关重要。讨论了通过利用疟疾疫苗和信使核糖核酸(mRNA)技术来促进进步的途径。
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