Abstract：
With the declining birth rates and aging societies in developed countries, the average age of the working population is increasing. Older people tend to get tired more easily, so prevention of fatigue is important to improve the quality of life for older workers. This study aimed to assess the mechanism of fatigue in older people, especially focused on relation between dysfunction of erythrocyte and fatigue. Total power (TP), which is the value of autonomic nerve activity, was measured as a value of fatigue and significantly decreased in workers with aging. As properties of senescent erythrocytes, the erythrocyte sedimentation rate and damaged erythrocytes population increased with aging and correlated with TP. These results suggested that the accumulation of damaged erythrocytes contributes to fatigue. Recent studies revealed that senescence-associated secretory phenotype (SASP), a phenomenon in which senescent cells secrete a variety of cytokines, affected hematopoiesis in bone marrow. We analyzed the effects of SASP factors on erythropoiesis and found that Interleukin -1α (IL-1α) suppressed erythrocyte differentiation of hematopoietic stem cells in vitro. We also showed that IL-1α levels in human blood and saliva increase with aging, suggesting the possibility that IL-1α level in saliva can be used to predict the decline in hematopoietic function.
摘要：
随着发达国家出生率的下降和社会的老龄化，劳动人口的平均年龄正在增加。老年人更容易疲劳,因此，预防疲劳对提高老年工人的生活质量很重要。这项研究旨在评估老年人疲劳的机制，尤其是研究红细胞功能障碍与疲劳的关系。总功率(TP),这是自主神经活动的价值，被测量为疲劳值，并且在年龄较大的工人中显着降低。作为衰老红细胞的特性，随着年龄的增长，红细胞沉降率和受损红细胞群增加，并与TP相关。这些结果表明，受损红细胞的积累有助于疲劳。最近的研究表明，衰老相关分泌表型（SASP），衰老细胞分泌多种细胞因子的现象，影响骨髓造血。我们分析了SASP因子对红细胞生成的影响，发现白细胞介素-1α（IL-1α）在体外抑制了造血干细胞的红细胞分化。我们还表明，人血液和唾液中的IL-1α水平随着年龄的增长而增加，这表明唾液中IL-1α水平可用于预测造血功能下降的可能性。
