Abstract：
Hyaluronic acid (HA) has emerged as a promising biopolymer for various biomedical applications due to its biocompatibility, biodegradability, and intrinsic ability to interact with cell surface receptors, making it an attractive candidate for drug delivery systems and tissue engineering. Chemical modification of HA has opened up versatile possibilities to tailor its properties, enabling the development of advanced drug delivery systems and biomaterials with enhanced functionalities and targeted applications. This review analyzes the strategies and applications of chemically modified HA in the field of drug delivery and biomaterial development. The first part of the review focuses on the different methods and functional groups used for the chemical modification of HA, highlighting the impact of these modifications on its physicochemical properties, degradation behavior and interactions with drugs. The second part of the review evaluates the use of chemically modified HA in the development of advanced biomedical materials including nano- and microparticles, hydrogels and mucoadhesive materials with tailored drug release profiles, site-specific targeting and stimuli-responsive behavior. Thus, the review consolidates the current advances and future perspectives in the field of chemical modification of HA, underscoring its immense potential to drive the development of advanced drug delivery systems and biomaterials with diverse biomedical applications.
摘要：
透明质酸（HA）由于其生物相容性，已成为各种生物医学应用的有前途的生物聚合物，生物降解性，以及与细胞表面受体相互作用的内在能力，使其成为药物递送系统和组织工程的有吸引力的候选者。HA的化学修饰为定制其性能开辟了多种可能性，能够开发具有增强功能和目标应用的先进药物输送系统和生物材料。本文综述了化学修饰的HA在药物递送和生物材料开发领域的策略和应用。综述的第一部分重点介绍了用于HA化学修饰的不同方法和官能团，强调这些修饰对其物理化学性质的影响，降解行为和与药物的相互作用。评论的第二部分评估了化学修饰的HA在开发包括纳米和微粒在内的先进生物医学材料中的用途，具有定制药物释放特性的水凝胶和粘膜粘附材料，位点特异性靶向和刺激响应行为。因此，该评论巩固了HA化学修饰领域的当前进展和未来前景，强调其巨大的潜力，推动先进的药物输送系统和生物材料的发展与不同的生物医学应用。
