Abstract：
Patients with Hashimoto\'s thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue, significantly elevated levels of interleukin 17 (IL-17), and an imbalance in the ratio of Th17 cells to regulatory T cells (Tregs). The reduced Tregs\' ratio leads to a reduction in immunosuppressive function within the thyroid gland, while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.
摘要：
桥本甲状腺炎患者血清和甲状腺组织中Th17细胞数量增加，白细胞介素17（IL-17）的水平显着升高，Th17细胞与调节性T细胞（Tregs）的比例失衡。Tregs比值的降低导致甲状腺内免疫抑制功能的降低，而Th17细胞通过调节甲状腺促炎细胞因子的表达参与HT的发生发展,并通过分泌IL-17介导甲状腺组织纤维化。
