Abstract：
BACKGROUND: Diagnosis with facial palsy (FP) has been linked to increased psychosocial distress and communication disorders, but limited data exist on the temporal development of depression and anxiety after diagnosis. In a large cohort of FP patients, we characterize the rates of depression and anxiety at several timepoints post-FP diagnosis.
METHODS: A de-identified database of all FP patients who presented to a single healthcare system over 22 years was created using Epic SlicerDicer. Demographics and comorbidities were collected and depression and anxiety diagnosis rates at three timepoints (non-inclusive lower bounds) post-FP diagnosis were examined.
RESULTS: 3,910 FP patients were identified, with a median age of 59. 56% were female and 51% were white. At 0-6, 6-12-, and 12-36-month post-FP diagnosis, 156 (4%), 58 (1.4%), and 205 (5.2%) individuals were diagnosed with depression, and 171 (4.4%), 84 (2.1%), and 237 (6.1%) were diagnosed with anxiety. At each time point, the median time between FP and depression diagnosis (2.1, 3.4, and 11.4 months) or anxiety diagnosis (2.5, 4.0, and 11.1 months) was similar. Dual depression and anxiety diagnoses were observed in 52 (1.3%), 32 (0.8%), and 122 (3.1%) patients at each time point. Compared to the overall cohort, more patients with anxiety were female (65 vs. 56%, p < 0.001) and younger (57 vs. 59, p = 0.002), and more depressed patients were Black (7.3 vs. 3.3%, p = 0.02).
CONCLUSIONS: Facial palsy may lead to increased risk of depression and/or anxiety in the first year after diagnosis as demonstrated here in one of the largest FP cohorts to date. We report high rates of depression (5.5%), anxiety (6.5%), and comorbid depression and anxiety (2.1%) occurring within 1 year after FP diagnosis. Of these, the majority occurred within the first 6 months (72%, 67%, 62%, respectively). Anxiety was more common in young female patients and depression more common in Black patients, which can inform targeted mental health resources within the first 6 months post-FP diagnosis.
METHODS: A de-identified database of all FP patients who presented to a single healthcare system over 22 years was created using Epic SlicerDicer. Demographics and comorbidities were collected and depression and anxiety diagnosis rates at three timepoints (non-inclusive lower bounds) post-FP diagnosis were examined.
RESULTS: 3,910 FP patients were identified, with a median age of 59. 56% were female and 51% were white. At 0-6, 6-12-, and 12-36-month post-FP diagnosis, 156 (4%), 58 (1.4%), and 205 (5.2%) individuals were diagnosed with depression, and 171 (4.4%), 84 (2.1%), and 237 (6.1%) were diagnosed with anxiety. At each time point, the median time between FP and depression diagnosis (2.1, 3.4, and 11.4 months) or anxiety diagnosis (2.5, 4.0, and 11.1 months) was similar. Dual depression and anxiety diagnoses were observed in 52 (1.3%), 32 (0.8%), and 122 (3.1%) patients at each time point. Compared to the overall cohort, more patients with anxiety were female (65 vs. 56%, p < 0.001) and younger (57 vs. 59, p = 0.002), and more depressed patients were Black (7.3 vs. 3.3%, p = 0.02).
CONCLUSIONS: Facial palsy may lead to increased risk of depression and/or anxiety in the first year after diagnosis as demonstrated here in one of the largest FP cohorts to date. We report high rates of depression (5.5%), anxiety (6.5%), and comorbid depression and anxiety (2.1%) occurring within 1 year after FP diagnosis. Of these, the majority occurred within the first 6 months (72%, 67%, 62%, respectively). Anxiety was more common in young female patients and depression more common in Black patients, which can inform targeted mental health resources within the first 6 months post-FP diagnosis.
摘要：
背景：诊断为面神经麻痹（FP）与心理社会困扰和沟通障碍增加有关，但是关于诊断后抑郁和焦虑的时间发展的数据有限。在一大群FP患者中，我们描述了FP诊断后几个时间点抑郁和焦虑的发生率.
方法：使用EpicSlicerDicer创建了一个经过22年向单一医疗系统就诊的所有FP患者的去识别数据库。收集人口统计学和合并症，并检查FP诊断后三个时间点（非包容性下限）的抑郁和焦虑诊断率。
结果：确定了3,910名FP患者，平均年龄为59岁。56%是女性，51%是白人。在0-6，6-12-，FP诊断后12-36个月，156（4%），58（1.4%），205人（5.2%）被诊断为抑郁症，和171（4.4%），84（2.1%），和237（6.1％）被诊断为焦虑。在每个时间点,FP与抑郁症诊断(2.1,3.4和11.4个月)或焦虑诊断(2.5,4.0和11.1个月)的中位时间相似.在52（1.3％）中观察到双重抑郁和焦虑诊断，32（0.8%），和122（3.1％）患者在每个时间点。与整体队列相比，更多的焦虑症患者是女性(65%vs.56%,p<0.001）和更年轻（57vs.59，p=0.002），更多的抑郁症患者是黑人(7.3%vs.3.3%,p=0.02)。
结论：在诊断后的第一年，面瘫可能导致抑郁和/或焦虑的风险增加，这是迄今为止最大的FP队列之一。我们报告抑郁症的发生率很高（5.5％），焦虑（6.5%），FP诊断后1年内出现抑郁和焦虑共病(2.1%)。其中,大多数发生在前6个月内(72%，67%,62%,分别)。焦虑在年轻女性患者中更常见，抑郁症在黑人患者中更常见，这可以在FP诊断后的前6个月内告知有针对性的精神卫生资源。
方法：使用EpicSlicerDicer创建了一个经过22年向单一医疗系统就诊的所有FP患者的去识别数据库。收集人口统计学和合并症，并检查FP诊断后三个时间点（非包容性下限）的抑郁和焦虑诊断率。
结果：确定了3,910名FP患者，平均年龄为59岁。56%是女性，51%是白人。在0-6，6-12-，FP诊断后12-36个月，156（4%），58（1.4%），205人（5.2%）被诊断为抑郁症，和171（4.4%），84（2.1%），和237（6.1％）被诊断为焦虑。在每个时间点,FP与抑郁症诊断(2.1,3.4和11.4个月)或焦虑诊断(2.5,4.0和11.1个月)的中位时间相似.在52（1.3％）中观察到双重抑郁和焦虑诊断，32（0.8%），和122（3.1％）患者在每个时间点。与整体队列相比，更多的焦虑症患者是女性(65%vs.56%,p<0.001）和更年轻（57vs.59，p=0.002），更多的抑郁症患者是黑人(7.3%vs.3.3%,p=0.02)。
结论：在诊断后的第一年，面瘫可能导致抑郁和/或焦虑的风险增加，这是迄今为止最大的FP队列之一。我们报告抑郁症的发生率很高（5.5％），焦虑（6.5%），FP诊断后1年内出现抑郁和焦虑共病(2.1%)。其中,大多数发生在前6个月内(72%，67%,62%,分别)。焦虑在年轻女性患者中更常见，抑郁症在黑人患者中更常见，这可以在FP诊断后的前6个月内告知有针对性的精神卫生资源。
