Abstract：
Gold standard method for the treatment of critical-sized bone defects is the autogenous bone grafting procedure. A number of new and potentially useful adjuncts currently are being investigated to enhance the success of bone grafting. We propose to evaluate the effect of the most known and easily obtained 2 biological materials, fat graft and platelet-rich plasma (PRP), on bone graft healing. Twenty-seven New Zealand male rabbits were included in this randomized, controlled study. Two-sided 15-mm diameter bone defects were created in the parietal bones and the bones taken were replaced right-to-left and vice versa with 1 control group, 1 fat graft applied group, and the last one PRP applied group. Histologic evaluation and 3-dimensional maxillofacial computerized tomography were performed and bone density was calculated. In radiologic analysis, bone density was significantly different in the PRP group compared with the control and fat graft group in the 12th week ( P <0.05). In histologic scoring analysis, the PRP group had a better score than the control and fat graft group, while the fat graft group was worse than the control group in the 6th week ( P <0.05). The addition of PRP had a positive effect whereas fat graft had a negative effect on bone graft healing compared with the control group.
摘要：
治疗临界骨缺损的金标准方法是自体骨移植程序。目前正在研究许多新的和潜在有用的辅助手段，以提高骨移植的成功率。我们建议评估最已知和最容易获得的2种生物材料的效果，脂肪移植物和富血小板血浆（PRP），骨移植愈合。27只新西兰雄性兔被纳入这个随机分组，对照研究。在顶骨中产生了双侧直径为15毫米的骨缺损，并将所采集的骨从右向左替换，反之亦然，对照组为1，1脂肪移植应用组，和最后一个PRP应用组。进行组织学评估和3维颌面部计算机断层扫描，并计算骨密度。在放射学分析中，12周PRP组与对照组和脂肪移植组的骨密度差异有统计学意义（P<0.05）。在组织学评分分析中，PRP组的评分优于对照组和脂肪移植组，第6周脂肪移植组比对照组差(P<0.05)。与对照组相比，添加PRP具有积极作用，而脂肪移植物对骨移植物愈合具有负面影响。
