PDF(Pubmed)
Abstract：
UNASSIGNED: To explore the role of ultraviolet radiation (UVR) in the occurrence and development of various ocular malignancies.
UNASSIGNED: In this article, we retrieved ocular malignancy data from the Global Cancer Observatory (GCO) and performed correlation analysis with the global UV index and sunshine duration. We searched for associated studies using the following databases: Embase, Pubmed, Cochrane Library, and Google Scholar. We conducted the literature by searching the Mesh terms denoting an exposure of interest (\"UV radiation\", \"ultraviolet rays\", and \"ocular malignancies\", All studies included are published until December 30, 2023 without language restrictions.
UNASSIGNED: The mechanisms and epidemiological statistics of UVR on the onset and progression of eyelid malignancies are the most studied and clear. The role of UVR in conjunctival melanoma is similar to that in eyelid melanoma. The relationship between uveal melanoma and UVR is controversial, however, it may have at least a certain impact on its prognosis. UVR causes ocular surface squamous neoplasia by further activating HPV infection.
UNASSIGNED: UVR is a decisive risk factor for ocular malignancies, but the incidence of ultraviolet-induced tumors is also affected by many other factors. A correct and comprehensive understanding of the mechanisms of UVR in the pathogenesis of ocular malignant tumors can provide patients with more effective and selective immune regulation strategies.
UNASSIGNED: In this article, we retrieved ocular malignancy data from the Global Cancer Observatory (GCO) and performed correlation analysis with the global UV index and sunshine duration. We searched for associated studies using the following databases: Embase, Pubmed, Cochrane Library, and Google Scholar. We conducted the literature by searching the Mesh terms denoting an exposure of interest (\"UV radiation\", \"ultraviolet rays\", and \"ocular malignancies\", All studies included are published until December 30, 2023 without language restrictions.
UNASSIGNED: The mechanisms and epidemiological statistics of UVR on the onset and progression of eyelid malignancies are the most studied and clear. The role of UVR in conjunctival melanoma is similar to that in eyelid melanoma. The relationship between uveal melanoma and UVR is controversial, however, it may have at least a certain impact on its prognosis. UVR causes ocular surface squamous neoplasia by further activating HPV infection.
UNASSIGNED: UVR is a decisive risk factor for ocular malignancies, but the incidence of ultraviolet-induced tumors is also affected by many other factors. A correct and comprehensive understanding of the mechanisms of UVR in the pathogenesis of ocular malignant tumors can provide patients with more effective and selective immune regulation strategies.
摘要：
■探讨紫外线（UVR）在各种眼部恶性肿瘤发生发展中的作用。
■在本文中，我们从全球癌症观察站(GCO)检索眼部恶性肿瘤数据,并与全球紫外线指数和日照时间进行相关性分析.我们使用以下数据库搜索相关研究：Embase，Pubmed,科克伦图书馆,谷歌学者。我们通过搜索表示感兴趣的暴露的网格术语(“紫外线辐射”，\"紫外线\",和“眼部恶性肿瘤”，所有纳入的研究都发表到2023年12月30日，没有语言限制。
■UVR对眼睑恶性肿瘤的发生和发展的机制和流行病学统计是研究最多和清楚的。UVR在结膜黑色素瘤中的作用与在眼睑黑色素瘤中的作用相似。葡萄膜黑色素瘤和UVR之间的关系是有争议的，然而,它可能至少对其预后有一定的影响。UVR通过进一步激活HPV感染而导致眼表鳞状细胞瘤形成。
■UVR是眼部恶性肿瘤的决定性危险因素，但是紫外线引起的肿瘤的发生也受到许多其他因素的影响。正确、全面地了解UVR在眼部恶性肿瘤发病中的作用机制,可以为患者提供更有效、更有选择性的免疫调节策略。
■在本文中，我们从全球癌症观察站(GCO)检索眼部恶性肿瘤数据,并与全球紫外线指数和日照时间进行相关性分析.我们使用以下数据库搜索相关研究：Embase，Pubmed,科克伦图书馆,谷歌学者。我们通过搜索表示感兴趣的暴露的网格术语(“紫外线辐射”，\"紫外线\",和“眼部恶性肿瘤”，所有纳入的研究都发表到2023年12月30日，没有语言限制。
■UVR对眼睑恶性肿瘤的发生和发展的机制和流行病学统计是研究最多和清楚的。UVR在结膜黑色素瘤中的作用与在眼睑黑色素瘤中的作用相似。葡萄膜黑色素瘤和UVR之间的关系是有争议的，然而,它可能至少对其预后有一定的影响。UVR通过进一步激活HPV感染而导致眼表鳞状细胞瘤形成。
■UVR是眼部恶性肿瘤的决定性危险因素，但是紫外线引起的肿瘤的发生也受到许多其他因素的影响。正确、全面地了解UVR在眼部恶性肿瘤发病中的作用机制,可以为患者提供更有效、更有选择性的免疫调节策略。
