PDF(Pubmed)
Abstract：
UNASSIGNED: Nuclear protein in testis (NUT) carcinoma is extremely rare, occurs in the midline of the body, progresses rapidly and is refractory to treatment; most patients die within a year. Here, we describe a case of maxillary sinus NUT carcinoma presenting with epistaxis and nasal obstruction that was treated as a standard head and neck carcinoma.
UNASSIGNED: The patient was a 41-year-old male with a left buccal swelling; the diagnosis was made of primary NUT carcinoma of the left maxillary sinus and bone metastasis in the cervical spine. After induction chemotherapy with docetaxel plus cisplatin and 5-fluorouracil, the tumor decreased in size, and the patient was further treated with cisplatin and radiation therapy. One month after that, the tumor remained small, however, lung metastasis was observed. Therefore, nivolumab was administered. Cetuximab and paclitaxel were administered after the lung metastasis worsened, but the patient developed progressive disease and died 11 months after diagnosis.
UNASSIGNED: Effective treatments for NUT carcinoma have not yet been established. However, early testing to establish the diagnosis may provide useful insights to guide clinical decisions to improve patient outcomes.
UNASSIGNED: The patient was a 41-year-old male with a left buccal swelling; the diagnosis was made of primary NUT carcinoma of the left maxillary sinus and bone metastasis in the cervical spine. After induction chemotherapy with docetaxel plus cisplatin and 5-fluorouracil, the tumor decreased in size, and the patient was further treated with cisplatin and radiation therapy. One month after that, the tumor remained small, however, lung metastasis was observed. Therefore, nivolumab was administered. Cetuximab and paclitaxel were administered after the lung metastasis worsened, but the patient developed progressive disease and died 11 months after diagnosis.
UNASSIGNED: Effective treatments for NUT carcinoma have not yet been established. However, early testing to establish the diagnosis may provide useful insights to guide clinical decisions to improve patient outcomes.
摘要：
■睾丸（NUT）癌中的核蛋白极为罕见，发生在身体的中线，进展迅速，难以治疗；大多数患者在一年内死亡。这里,我们描述了一例上颌窦NUT癌，表现为鼻出血和鼻塞，被视为标准头颈部癌。
■患者为一名41岁男性，左颊部肿胀；诊断为左侧上颌窦原发性NUT癌和颈椎骨转移。多西他赛联合顺铂和5-氟尿嘧啶诱导化疗后，肿瘤大小减小,患者接受了顺铂和放射治疗。一个月后,肿瘤仍然很小，然而,观察到肺转移。因此,使用nivolumab.在肺转移恶化后给予西妥昔单抗和紫杉醇，但患者发展为进行性疾病，并在诊断后11个月死亡。
■尚未建立NUT癌的有效治疗方法。然而,建立诊断的早期测试可能为指导临床决策提供有用的见解，以改善患者的预后。
■患者为一名41岁男性，左颊部肿胀；诊断为左侧上颌窦原发性NUT癌和颈椎骨转移。多西他赛联合顺铂和5-氟尿嘧啶诱导化疗后，肿瘤大小减小,患者接受了顺铂和放射治疗。一个月后,肿瘤仍然很小，然而,观察到肺转移。因此,使用nivolumab.在肺转移恶化后给予西妥昔单抗和紫杉醇，但患者发展为进行性疾病，并在诊断后11个月死亡。
■尚未建立NUT癌的有效治疗方法。然而,建立诊断的早期测试可能为指导临床决策提供有用的见解，以改善患者的预后。
