UNASSIGNED: A total of 116 renal transplant recipients, who had not been diagnosed with malignancies between January 2012 and December 2019, were included, and tumor markers were investigated.
UNASSIGNED: CEA showed a significant decrease after kidney transplantation, regardless of the dialysis type (3.6→2.6 ng/ml, p<0.001), while other tumor markers showed a significant increase (AFP: 3.6→3.7 ng/ml; CA19-9: 16.2→19.5 U/ml; PSA: 0.95→1.05 ng/ml; all p<0.05). Pre- and postoperative eGFR ratios and postoperative liver function were identified as factors influencing the postoperative CEA and CA19-9 values, while PSA was influenced by the duration of dialysis. No statistically significant factors were found for AFP levels.
UNASSIGNED: Caution should be exercised when investigating tumor markers in patients with renal dysfunction, as tumor marker levels may vary depending on the pathophysiology of each patient.
■共有116名肾移植受者,在2012年1月至2019年12月期间未被诊断出患有恶性肿瘤的人,包括在内,和肿瘤标志物进行了调查。
■肾移植后CEA显著下降,无论透析类型如何(3.6→2.6ng/ml,p<0.001),而其他肿瘤标志物显示显着升高(AFP:3.6→3.7ng/ml;CA19-9:16.2→19.5U/ml;PSA:0.95→1.05ng/ml;所有p<0.05)。术前和术后eGFR比值和术后肝功能被确定为影响术后CEA和CA19-9值的因素,而PSA受透析时间的影响。AFP水平没有发现统计学上有意义的因素。
■在研究肾功能不全患者的肿瘤标志物时应谨慎行事,因为肿瘤标志物水平可能根据每个患者的病理生理学而变化。