PDF(Pubmed)
Abstract：
UNASSIGNED: The claustrum (CLA), a subcortical area between the insular cortex and striatum, innervates almost all cortical regions of the mammalian brain. There is growing evidence that CLA participates in many brain functions, including memory, cognition, and stress response. It is proposed that dysfunction or malfunction of the CLA might be the pathology of some brain diseases, including stress-induced depression and anxiety. However, the role of the CLA in fear memory and anxiety disorders remains largely understudied.
UNASSIGNED: We evaluated the influences of neurotoxic lesions of the CLA using auditory-cued fear memory and anxiety-like behaviors in rats.
UNASSIGNED: We found that lesions of anterior CLA (aCLA) but not posterior CLA (pCLA) before fear conditioning attenuated fear retrieval, facilitated extinction, and reduced freezing levels during the extinction retention test. Post-learning lesions of aCLA but not pCLA facilitated fear extinction and attenuated freezing behavior during the extinction retention test. Lesions of aCLA or pCLA did not affect anxiety-like behaviors evaluated by the open field test and elevated plus-maze test.
UNASSIGNED: These data suggested that aCLA but not pCLA was involved in fear memory and extinction. Future studies are needed to further investigate the anatomical and functional connections of aCLA subareas that are involved in fear conditioning, which will deepen our understanding of CLA functions.
UNASSIGNED: We evaluated the influences of neurotoxic lesions of the CLA using auditory-cued fear memory and anxiety-like behaviors in rats.
UNASSIGNED: We found that lesions of anterior CLA (aCLA) but not posterior CLA (pCLA) before fear conditioning attenuated fear retrieval, facilitated extinction, and reduced freezing levels during the extinction retention test. Post-learning lesions of aCLA but not pCLA facilitated fear extinction and attenuated freezing behavior during the extinction retention test. Lesions of aCLA or pCLA did not affect anxiety-like behaviors evaluated by the open field test and elevated plus-maze test.
UNASSIGNED: These data suggested that aCLA but not pCLA was involved in fear memory and extinction. Future studies are needed to further investigate the anatomical and functional connections of aCLA subareas that are involved in fear conditioning, which will deepen our understanding of CLA functions.
摘要：
■claustrum(CLA)，岛叶皮层和纹状体之间的皮层下区域，神经支配哺乳动物大脑的几乎所有皮质区域。越来越多的证据表明，CLA参与了许多大脑功能，包括记忆，认知，和应激反应。有人认为，CLA的功能障碍或功能障碍可能是某些脑部疾病的病理。包括压力引起的抑郁和焦虑。然而,CLA在恐惧记忆和焦虑症中的作用仍未得到充分研究.
■我们使用听觉提示的恐惧记忆和焦虑样行为评估了CLA神经毒性病变的影响。
■我们发现前CLA（aCLA）而不是后CLA（pCLA）的损伤在恐惧条件下减弱了恐惧恢复，促进灭绝，并在消光保持试验期间降低冻结水平。在灭绝保留测试期间，aCLA而不是pCLA的学习后病变促进了恐惧灭绝并减弱了冻结行为。aCLA或pCLA的病变不会影响通过开放场测试和高架迷宫测试评估的焦虑样行为。
■这些数据表明，aCLA而不是pCLA参与了恐惧记忆和灭绝。未来的研究需要进一步调查与恐惧条件有关的aCLA子区域的解剖和功能连接，这将加深我们对CLA功能的理解。
■我们使用听觉提示的恐惧记忆和焦虑样行为评估了CLA神经毒性病变的影响。
■我们发现前CLA（aCLA）而不是后CLA（pCLA）的损伤在恐惧条件下减弱了恐惧恢复，促进灭绝，并在消光保持试验期间降低冻结水平。在灭绝保留测试期间，aCLA而不是pCLA的学习后病变促进了恐惧灭绝并减弱了冻结行为。aCLA或pCLA的病变不会影响通过开放场测试和高架迷宫测试评估的焦虑样行为。
■这些数据表明，aCLA而不是pCLA参与了恐惧记忆和灭绝。未来的研究需要进一步调查与恐惧条件有关的aCLA子区域的解剖和功能连接，这将加深我们对CLA功能的理解。
