PDF(Pubmed)
Abstract：
UNASSIGNED: Ondansetron reduces the median effective dose (ED50) of prophylactic phenylephrine to prevent spinal-induced hypotension (SIH) during cesarean delivery. However, the exact dose response of phenylephrine in combination with prophylactic ondansetron for preventing SIH is unknown. Therefore, this study aimed to determine the dose-response of phenylephrine to prevent SIH in cesarean delivery when 4 mg of ondansetron was used as a preventive method.
UNASSIGNED: A total of 80 parturients were enrolled and divided randomly into four groups (n = 20 in each group) who received either 0.2, 0.3, 0.4, or 0.5 μg/kg/min of prophylactic phenylephrine. Ten minutes before the initiation of spinal induction, 4 mg prophylactic ondansetron was administered. The effective dose of prophylactic phenylephrine was defined as the dose required to prevent hypotension after the period of intrathecal injection and up to neonatal delivery. The ED50 and ED90 of prophylactic phenylephrine and 95% confidence intervals (95% CI) were calculated using probit analysis.
UNASSIGNED: The ED50 and ED90 for prophylactic phenylephrine to prevent SIH were 0.25 (95% CI, 0.15 to 0.30), and 0.45 (95% CI, 0.39 to 0.59) μg/kg/min, respectively. No significant differences were observed in the side effects and neonatal outcomes between the four groups.
UNASSIGNED: The administration of 4 mg of prophylactic ondansetron was associated with an ED50 of 0.25 (95% CI, 0.15~0.30) and ED90 of 0.45 (95% CI, 0.39~0.59) μg/kg/min for phenylephrine to prevent SIH.
UNASSIGNED: A total of 80 parturients were enrolled and divided randomly into four groups (n = 20 in each group) who received either 0.2, 0.3, 0.4, or 0.5 μg/kg/min of prophylactic phenylephrine. Ten minutes before the initiation of spinal induction, 4 mg prophylactic ondansetron was administered. The effective dose of prophylactic phenylephrine was defined as the dose required to prevent hypotension after the period of intrathecal injection and up to neonatal delivery. The ED50 and ED90 of prophylactic phenylephrine and 95% confidence intervals (95% CI) were calculated using probit analysis.
UNASSIGNED: The ED50 and ED90 for prophylactic phenylephrine to prevent SIH were 0.25 (95% CI, 0.15 to 0.30), and 0.45 (95% CI, 0.39 to 0.59) μg/kg/min, respectively. No significant differences were observed in the side effects and neonatal outcomes between the four groups.
UNASSIGNED: The administration of 4 mg of prophylactic ondansetron was associated with an ED50 of 0.25 (95% CI, 0.15~0.30) and ED90 of 0.45 (95% CI, 0.39~0.59) μg/kg/min for phenylephrine to prevent SIH.
摘要：
■昂丹司琼降低预防性去氧肾上腺素的中位有效剂量（ED50），以预防剖宫产期间的脊髓性低血压（SIH）。然而,去氧肾上腺素联合预防性昂丹司琼预防SIH的确切剂量反应尚不清楚.因此,本研究旨在确定当4mg昂丹司琼用作预防方法时,去氧肾上腺素预防剖宫产中SIH的剂量-反应.
■共纳入80例产妇，随机分为四组（每组20例），分别接受0.2、0.3、0.4或0.5μg/kg/min的预防性去氧肾上腺素。脊髓诱导开始前十分钟，给予4mg预防性昂丹司琼。预防性去氧肾上腺素的有效剂量定义为在鞘内注射期至新生儿分娩后预防低血压所需的剂量。使用概率分析计算预防性去氧肾上腺素的ED50和ED90以及95%置信区间(95%CI)。
■预防性去氧肾上腺素预防SIH的ED50和ED90为0.25（95％CI，0.15至0.30），和0.45(95%CI，0.39至0.59)μg/kg/min，分别。四组之间的副作用和新生儿结局没有显着差异。
■服用4mg预防性昂丹司琼与去氧肾上腺素的ED50为0.25（95％CI，0.15〜0.30）和ED90为0.45（95％CI，0.39〜0.59）μg/kg/min相关，以预防SIH。
■共纳入80例产妇，随机分为四组（每组20例），分别接受0.2、0.3、0.4或0.5μg/kg/min的预防性去氧肾上腺素。脊髓诱导开始前十分钟，给予4mg预防性昂丹司琼。预防性去氧肾上腺素的有效剂量定义为在鞘内注射期至新生儿分娩后预防低血压所需的剂量。使用概率分析计算预防性去氧肾上腺素的ED50和ED90以及95%置信区间(95%CI)。
■预防性去氧肾上腺素预防SIH的ED50和ED90为0.25（95％CI，0.15至0.30），和0.45(95%CI，0.39至0.59)μg/kg/min，分别。四组之间的副作用和新生儿结局没有显着差异。
■服用4mg预防性昂丹司琼与去氧肾上腺素的ED50为0.25（95％CI，0.15〜0.30）和ED90为0.45（95％CI，0.39〜0.59）μg/kg/min相关，以预防SIH。
