关键词： (1,3)-beta-D-glucan Candida albicans cerebrospinal fluid chronic meningitis metagenomic next-generation sequencing ventriculitis

Mesh ： Humans High-Throughput Nucleotide Sequencing Adult Candida albicans / genetics isolation & purification Meningitis, Fungal / diagnosis microbiology drug therapy Metagenomics / methods Candidiasis / diagnosis microbiology cerebrospinal fluid Male Chronic Disease Antifungal Agents / therapeutic use Meningitis, Aseptic / diagnosis

来  源：   DOI：10.3389/fcimb.2024.1322847   PDF(Pubmed)

Abstract：
The aetiology of chronic aseptic meningitis is difficult to establish. Candida meningitis in particular is often diagnosed late, as cerebrospinal fluid (CSF) work-up and imaging findings are nonspecific. A 35-year-old patient with chronic aseptic meningitis, for which repeated microbiological testing of CSF was unrevealing, was finally diagnosed with Candida albicans (C. albicans) meningitis with cauda equina involvement using metagenomic next-generation sequencing (mNGS). This report highlights the diagnostic challenges and the difficulties of treating shunt-associated fungal meningitis.
摘要：
慢性无菌性脑膜炎的病因很难确定。尤其是念珠菌脑膜炎通常被诊断为晚期，脑脊液（CSF）检查和影像学检查结果是非特异性的。一名35岁的慢性无菌性脑膜炎患者，对CSF进行反复的微生物测试并没有发现，最终被诊断为白色念珠菌(C.白色念珠菌）使用宏基因组下一代测序（mNGS）参与马尾神经的脑膜炎。本报告强调了治疗分流相关真菌性脑膜炎的诊断挑战和困难。
公众号