PDF(Pubmed)
Abstract：
An increasing amount of research has shown that glycosylation plays a crucial role in autoimmune diseases (ADs), prompting our interest in conducting research on the knowledge framework and hot topics in this field based on bibliometric analysis. Studies on glycosylation in the field of ADs from 2003 to 2023 were collected by searching the Web of Science Core Collection database. Bibliometric analysis was conducted using VOSviewer, CiteSpace, and Bibliometrix software. This study included a total of 530 studies. According to the H, G, and M indices, the United States has made the most contributions worldwide, with China making significant contributions in recent years. Leiden University from the Netherlands ranks among the top institutions in terms of publication and citation rankings, with the institution\'s author Manfred Wuhrer contributing the most to this field. Frontiers in Immunology is the journal with the highest H-index. Research in this field has focused on antibody glycosylation, particularly the specific glycosylation of IgG and IgA, and its role in various ADs. The application of glycoengineering glycosylated proteins in the synthesis of targeted monoclonal antibodies, drug delivery, and regenerative medical materials may be a new trend in the treatment of ADs. Artificial intelligence is an emerging tool in glycobiology. This study summarizes the objective data on glycosylation in the field of AD publications in recent years, providing a reference for researchers in this field.
摘要：
越来越多的研究表明，糖基化在自身免疫性疾病（ADs）中起着至关重要的作用。激发了我们对基于文献计量分析的知识框架和该领域的热门话题进行研究的兴趣。通过搜索WebofScienceCoreCollection数据库收集了2003年至2023年AD领域中的糖基化研究。使用VOSviewer进行文献计量分析，CiteSpace,和Bibliometrix软件。本研究共纳入530项研究。根据H,G,和M指数，美国在世界范围内做出了最多的贡献，近年来，中国做出了重大贡献。荷兰莱顿大学在出版物和引文排名方面名列前茅，该机构的作者ManfredWuhrer对这一领域贡献最大。免疫学前沿是H指数最高的杂志。该领域的研究主要集中在抗体糖基化，特别是IgG和IgA的特异性糖基化，以及它在各种广告中的作用。糖工程糖基化蛋白在靶向单克隆抗体合成中的应用,药物输送,再生医用材料可能是ADs治疗的新趋势。人工智能是糖生物学的新兴工具。本研究总结了近年来AD领域有关糖基化的客观数据,为该领域的研究者提供参考。
