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Abstract：
E3 ubiquitin ligases comprise a family of ubiquitination-catalyzing enzymes that have been extensively researched and are considered crucial components of the ubiquitin-proteasome system involved in various diseases. The ubiquitin-protein ligase E3 component n-recognition 5 (UBR5) is an E3 ubiquitin-protein ligase that has garnered considerable interest of late. Recent studies demonstrate that UBR5 undergoes high-frequency mutations, chromosomal amplification, and/or abnormalities during expression of various malignant tumors. These alterations correlate with the biological behaviors and prognoses of malignancies, such as tumor invasion, metastasis, and resistance to chemotherapeutic agents. This study aimed to comprehensively elucidate the biological functions of UBR5, and its role and relevance in the context of gastrointestinal cancers. Furthermore, this article expounds a scientific basis to explore the molecular mechanisms underlying gastrointestinal cancers and developing targeted therapeutic strategies for their remediation.
摘要：
E3泛素连接酶包含泛素化催化酶家族，已被广泛研究，被认为是涉及各种疾病的泛素-蛋白酶体系统的关键成分。泛素-蛋白连接酶E3组分n-识别5(UBR5)是一种E3泛素-蛋白连接酶,最近引起了相当大的兴趣。最近的研究表明，UBR5经历高频突变，染色体扩增,和/或各种恶性肿瘤表达过程中的异常。这些改变与恶性肿瘤的生物学行为和预后相关，如肿瘤侵袭，转移,和对化学治疗剂的抗性。本研究旨在全面阐明UBR5的生物学功能及其在胃肠道肿瘤中的作用和相关性。此外，本文阐述了探索胃肠道肿瘤的分子机制和开发针对其治疗的靶向治疗策略的科学依据。
