PDF(Pubmed)
Abstract：
UNASSIGNED: To compare the survival outcomes between male and female patients with intrahepatic cholangiocarcinoma who underwent liver resection.
UNASSIGNED: Data from 976 consecutive intrahepatic cholangiocarcinoma patients undergoing liver resection between January 2005 and May 2013 at the Eastern Hepatobiliary Surgery Hospital were prospectively collected and retrospectively reviewed. Patient clinicopathological characteristics, overall survival, and cumulative recurrence rates were compared between male and female patients using propensity score matching.
UNASSIGNED: Propensity score matching generated 313 matched pairs of patients. Among the entire cohort, the 1-, 3-, and 5-year overall survival and recurrence rates of the male and female patients were 60.2 %, 37.3 %, and 27.7 % vs. 65.8 %, 40.4 %, and 31.0 % (P = 0.380) and 50.6 %, 67.4 %, and 74.2 % vs. 44.4 %, 63.5 %, and 69.6 % (P = 0.123), respectively. In the matched cohort, the 1-, 3-, and 5-year overall survival and recurrence rates of the male and female patients were 60.6 %, 35.9 % and 22.4 % vs. 66.4 %, 40.6 % and 31.1 % (P = 0.041) and 51.5 %, 69.3 % and 83.9 % vs. 44.3 %, 63.6 %, and 69.9 % (P = 0.041), respectively. After adjustment for other confounding variables by multivariate Cox regression analysis, male sex was independently associated with worse overall survival (hazard ratio = 1.322, 95 % confidence interval: 1.079-1.621, P = 0.007) and tumor recurrence (hazard ratio = 1.337, 95 % confidence interval: 1.088-1.645, P = 0.006). A subgroup analysis of patients younger than 55 years old after propensity score matching showed that male patients had significantly worse overall survival and higher recurrence rates than female patients after surgery, while no significant difference in long-term overall survival and recurrence was observed between male and female patients older than 55 years old after propensity score matching.
UNASSIGNED: Male sex was an independent risk factor for overall survival and tumor recurrence in patients after liver resection for intrahepatic cholangiocarcinoma.
UNASSIGNED: Data from 976 consecutive intrahepatic cholangiocarcinoma patients undergoing liver resection between January 2005 and May 2013 at the Eastern Hepatobiliary Surgery Hospital were prospectively collected and retrospectively reviewed. Patient clinicopathological characteristics, overall survival, and cumulative recurrence rates were compared between male and female patients using propensity score matching.
UNASSIGNED: Propensity score matching generated 313 matched pairs of patients. Among the entire cohort, the 1-, 3-, and 5-year overall survival and recurrence rates of the male and female patients were 60.2 %, 37.3 %, and 27.7 % vs. 65.8 %, 40.4 %, and 31.0 % (P = 0.380) and 50.6 %, 67.4 %, and 74.2 % vs. 44.4 %, 63.5 %, and 69.6 % (P = 0.123), respectively. In the matched cohort, the 1-, 3-, and 5-year overall survival and recurrence rates of the male and female patients were 60.6 %, 35.9 % and 22.4 % vs. 66.4 %, 40.6 % and 31.1 % (P = 0.041) and 51.5 %, 69.3 % and 83.9 % vs. 44.3 %, 63.6 %, and 69.9 % (P = 0.041), respectively. After adjustment for other confounding variables by multivariate Cox regression analysis, male sex was independently associated with worse overall survival (hazard ratio = 1.322, 95 % confidence interval: 1.079-1.621, P = 0.007) and tumor recurrence (hazard ratio = 1.337, 95 % confidence interval: 1.088-1.645, P = 0.006). A subgroup analysis of patients younger than 55 years old after propensity score matching showed that male patients had significantly worse overall survival and higher recurrence rates than female patients after surgery, while no significant difference in long-term overall survival and recurrence was observed between male and female patients older than 55 years old after propensity score matching.
UNASSIGNED: Male sex was an independent risk factor for overall survival and tumor recurrence in patients after liver resection for intrahepatic cholangiocarcinoma.
摘要：
■比较接受肝切除术的男性和女性肝内胆管癌患者的生存结果。
■前瞻性收集并回顾性分析了2005年1月至2013年5月在东部肝胆外科医院接受肝切除术的976例连续肝内胆管癌患者的数据。患者临床病理特征,总生存率,使用倾向评分匹配比较男性和女性患者的累积复发率。
■倾向评分匹配产生313对匹配的患者。在整个队列中，1-,3-,男性和女性患者的5年总生存率和复发率为60.2%，37.3%,和27.7%与65.8%,40.4%,和31.0%(P=0.380)和50.6%，67.4%,和74.2%vs.44.4%,63.5%,和69.6%(P=0.123)，分别。在匹配的队列中，1-,3-,男性和女性患者的5年总生存率和复发率为60.6%，35.9%和22.4%vs.66.4%,40.6％和31.1％（P=0.041）和51.5％，69.3%和83.9%与44.3%,63.6%,69.9%(P=0.041)，分别。在通过多变量Cox回归分析调整其他混杂变量后，男性与较差的总生存期(风险比=1.322,95%置信区间:1.079-1.621,P=0.007)和肿瘤复发(风险比=1.337,95%置信区间:1.088-1.645,P=0.006)独立相关.对年龄小于55岁的患者进行倾向评分匹配后的亚组分析显示,男性患者术后总生存率明显低于女性患者,复发率较高,而在倾向评分匹配后,年龄超过55岁的男性和女性患者的长期总生存率和复发率没有显著差异.
■男性性别是肝内胆管癌患者肝切除术后总生存期和肿瘤复发的独立危险因素。
■前瞻性收集并回顾性分析了2005年1月至2013年5月在东部肝胆外科医院接受肝切除术的976例连续肝内胆管癌患者的数据。患者临床病理特征,总生存率,使用倾向评分匹配比较男性和女性患者的累积复发率。
■倾向评分匹配产生313对匹配的患者。在整个队列中，1-,3-,男性和女性患者的5年总生存率和复发率为60.2%，37.3%,和27.7%与65.8%,40.4%,和31.0%(P=0.380)和50.6%，67.4%,和74.2%vs.44.4%,63.5%,和69.6%(P=0.123)，分别。在匹配的队列中，1-,3-,男性和女性患者的5年总生存率和复发率为60.6%，35.9%和22.4%vs.66.4%,40.6％和31.1％（P=0.041）和51.5％，69.3%和83.9%与44.3%,63.6%,69.9%(P=0.041)，分别。在通过多变量Cox回归分析调整其他混杂变量后，男性与较差的总生存期(风险比=1.322,95%置信区间:1.079-1.621,P=0.007)和肿瘤复发(风险比=1.337,95%置信区间:1.088-1.645,P=0.006)独立相关.对年龄小于55岁的患者进行倾向评分匹配后的亚组分析显示,男性患者术后总生存率明显低于女性患者,复发率较高,而在倾向评分匹配后,年龄超过55岁的男性和女性患者的长期总生存率和复发率没有显著差异.
■男性性别是肝内胆管癌患者肝切除术后总生存期和肿瘤复发的独立危险因素。
