PDF(Pubmed)
Abstract：
We describe a rare case of capecitabine-induced palmar-plantar erythrodysesthesia (PPE), or hand-foot syndrome (HFS), involving the genitals, which resolved with tacrolimus therapy, in a patient with cT3dN3 stage IIIc moderately differentiated proximal rectal adenocarcinoma who was undergoing neoadjuvant chemotherapy. Given its severe impact on the quality of life, HFS often requires independent local anti-inflammatory treatment and subsequent dose delay and/or modification of the patient\'s chemotherapy. We believe that our findings in this report can aid clinicians in the early recognition and management of capecitabine-associated HFS resulting in balanitis, as prompt treatment may reduce morbidity and avoid prolonged interruption of chemotherapy in these patients.
摘要：
我们描述了一例罕见的卡培他滨诱导的掌足红肿感觉障碍（PPE），或手足综合征（HFS），涉及生殖器，用他克莫司治疗解决了，在接受新辅助化疗的cT3dN3期IIIc中分化近端直肠腺癌患者中。鉴于其对生活质量的严重影响，HFS通常需要独立的局部抗炎治疗和随后的剂量延迟和/或修改患者的化疗。我们相信，我们在本报告中的发现可以帮助临床医生早期识别和管理导致龟头炎的卡培他滨相关HFS。因为在这些患者中，及时治疗可以降低发病率并避免长期中断化疗。
